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Deep-brain stimulation in freely behaving mice can be achieved via wide-field near-infrared illumination and stereotactically injected photothermal transducers activating neurons ectopically expressing a temperature-sensitive cation channel.
Organoid models of intestinal stem cell differentiation into Paneth cells allow for the identification, via high-throughput phenotypic screening, of biological targets and small molecules regulating the composition of intestinal epithelium.
An inexpensive knotted catheter-like device made of a piezoresistive elastic silicone–liquid-metal composite performs comparably to commercial manometry devices for the sensing of gastrointestinal motility in anaesthetized pigs.
A one-step fluorescence assay relying on suboptimal protospacer adjacent motifs for Cas12a detects SARS-CoV-2 RNA in nasopharyngeal samples in less than 20 minutes with a sensitivity comparable to that of RT–qPCR.
The combination of massively parallel mutation enrichment and duplex sequencing allows for the tracking of up to 10,000 low-frequency mutations with up to 100-fold fewer reads per locus than conventional duplex sequencing.
Cells in large heterogeneous cell populations can be selectively photolabelled according to specific functional dynamics via an optical microscope with an ultrawide field of view, fast image analysis and a photoactivatable dye.
Ovarian cancer can be predicted with high sensitivity and specificity via a fingerprint obtained, via machine learning, from near-infrared fluorescence emissions of an array of carbon nanotube sensors in serum samples.
Multi-arm junction RNAs integrating motifs for loop-initiated RNA activators enable the execution of molecular logic independent of RNA-input sequence, thus facilitating the design of cell-free diagnostics.
Double-blinded studies show that paper-based diagnostic tests and a companion portable device designed for use in low-resource settings perform well for the diagnosis of the Zika and chikungunya viruses in serum samples.
In vivo lensless imaging can be achieved via a phase mask that creates diffraction patterns with high-contrast contours, as shown for the imaging of calcium dynamics in the cortex of mice and of microvasculature in the oral mucosa of volunteers.
A library of protease-cleavable sensors conjugated to antibodies against the programmed cell death protein 1 allows for the urinary detection of early antitumour responses to immune checkpoint blockade therapy and of resistance to it in mice.
Potent chimaeric antigen receptor T cells can be generated within one day from T cells derived from peripheral blood without the need for T-cell activation.
A nanoscale metal–organic framework that modulates the immunological and mechanical properties of the tumour microenvironment enhances the outcomes of radiotherapy–radiodynamic therapy, especially when combined with checkpoint blockade.
The delivery of oligonucleotides disrupting the secondary structure of single-guide RNAs and of short interfering RNAs targeting Cas9 mRNA can enhance lipid-nanoparticle-mediated gene editing in vivo in tissues other than the liver.
The performance of microbubble-localization algorithms for use in ultrasound localization microscopy can now be easily benchmarked via openly available algorithms and datasets of simulated microcirculation and of in vivo and ex vivo angiography.
RNA-binding proteins acting as decoys for pathogenic expanded CUG RNA repeats reverse the toxicity of the mutant transcripts in muscle cells derived from a patient with myotonic dystrophy type 1 and in a mouse model of the disease.
A self-assembled DNA-based system immobilized on a liquid-gated graphene field-effect transistor can electromechanically detect ultralow levels of unamplified ions, nucleic acids, small molecules and proteins in biofluids.
High-mannose N-linked glycans, which are abundantly expressed on the surface of human mesenchymal stromal cells, can serve as a biomarker for the in vivo tracking of the cells via chemical exchange saturation transfer magnetic resonance imaging.
Flagellated bacteria coated with antigen-adsorbing polymer nanoparticles and injected into tumours in mice after radiotherapy elicit systemic antitumour effects by transporting antigens to the tumour’s periphery.