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A custom-made fidget spinner rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification.
The co-administration of insulin and pramlintide stabilized with cucurbit[7]uril-conjugated polyethylene glycol in diabetic pigs improves the mealtime suppression of glucagon over the separate administration of the two hormones.
Target-specific peptides that resist gastrointestinal proteases when delivered orally into mice can be generated via the evolution and selection of double-bridged peptides through in vitro protease-resistant-phage display.
A robotically handled culture system using porcine gastrointestinal tissue explants for the high-throughput interrogation of the gastrointestinal tract predicts the absorption of oral drugs in the human gut better than Caco-2 Transwells.
A plasmonic nanoscale construct serving as a customizable ‘add-on’ fluorescent label improves the signal-to-noise ratio and dynamic range of a range of fluorescence-based bioassays.
Neural activity residing in a low-dimensional space that reflects specific correlation patterns among neurons can be used to maintain the performance of brain–computer interfaces in the presence of recording instabilities.
Cardiac organoids incorporating an oxygen-diffusion gradient and stimulated with the neurotransmitter noradrenaline can model the structure and function of the human heart after myocardial infarction.
A fast and inexpensive point-of-care assay based on CRISPR–Cas13 accurately detects the DNA of opportunistic viruses in blood and urine samples as well as an mRNA marker of renal transplant rejection in urine samples.
A collagen-binding interleukin-12 formulation intravenously injected into mice bearing established immunologically cold mouse tumours led to marked tumour remission, particularly when combined with checkpoint-inhibitor immunotherapy.
A ‘smart’ toilet that uses pressure and motion sensors, biometric identification, urinalysis strips, a computer-vision uroflowmeter and machine learning longitudinally tracks biomarkers of health and disease in the user’s urine and stool.
A retrievable, porous and anti-fibrotic macrodevice for the encapsulation of cells provides long-term protection to human cells expressing therapeutic proteins after device implantation in the intraperitoneal space of immunocompetent mice.
Intravenously injected functionalized carbon quantum dots that bind to the large neutral amino acid transporter 1 and that structurally mimic large amino acids selectively accumulate in human tumours in mice, facilitating targeted theranostics.
A fluorescently labelled inhibitor of the DNA repair enzyme poly(ADP–ribose) polymerase 1 is used to detect epithelial cancers of the upper intestinal tract in animals, in biopsied human tissue and in a human patient.
High-resolution raster-scanning optoacoustic mesoscopy provides detailed morphological and physiological insights into the responses of tumours to vascular-targeted therapies.
A cyclic octapeptide labelled with a near-infrared dye and that binds, with high affinity at high levels of calcium, to phosphorylated protein Annexin A2 in a range of solid tumours, serves as a tumour-selective imaging probe.
A wireless and battery-free 1.7-mm3 neural stimulator implanted onto the sciatic nerve of rats allows for repeatable stimulation across a range of physiological responses.
A reconfigurable nanophotonic silicon probe, implanted in anaesthetized mice, that switches multiple optical beams in less than 20 μs enables the optical stimulation of multineuron spike patterns in the brain at sub-millisecond precision.
A single removable transdermal patch bearing microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix regulates blood glucose in insulin-deficient diabetic mice and minipigs.
An optofluidic device rapidly detects, via surface-enhanced Raman scattering, picomolar concentrations of biomarkers for traumatic brain injury in finger-prick blood samples from patients.
FeCo nanoparticles with a graphitic carbon shell decorated with poly(ethylene glycol) have photothermal and magnetothermal properties and are sensitive tracers for magnetic particle imaging, magnetic resonance imaging and photoacoustic imaging.