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Machine-learning algorithms trained with retinal fundus images, with
subject metadata or with both data types, predict haemoglobin concentration with
mean absolute errors lower than 0.75 g dl–1 and anaemia
with areas under the curve in the range of 0.74–0.89.
Structural and functional analyses of the remodelling of intact lymphatic vasculature after the ligation of a hind-limb lymphatic vessel in sheep reveal the adaptations to the changes in fluid load that occur after lymphatic injury.
An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients.
A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.
Micropatterned nitinol (a nickel titanium alloy) thin films loaded with human CAR-T cells and implanted into tumours foster the expansion of the cells and extend animal survival in mouse models of human tumours.
A non-invasive biomarker of the degree of collective order of monolayers of corneal endothelial cells cultured for transplantation predicts the long-term prognosis of corneal restoration in patients.
The simultaneous removal of endogenous T-cell receptor α-chains and β-chains, and the orthotopic placement of an exogenous receptor in human T cells via CRISPR gene-editing, prevents the mispairing between endogenous and transgenic receptors while preserving the cells’ function.
In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.
A near-infrared-light-sensitive photovoltaic subretinal prosthesis triggers behavioural responses in awake macaques, even two years after device implantation.
The local delivery of a calcium channel blocker and a Rho-kinase inhibitor, determined by screening for small molecules that cause ureteral relaxation, significantly reduce ureteral contraction in pigs.
Pink-beam synchrotron X-ray tomography combined with mechanical loading at nanometric precision enables the in situ imaging of intact untreated joints, resolving strains at sub-100 nm resolution.
A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.
The serial assessment of the functional parameters of leukocytes isolated via an inertial microfluidic system from 50 μl of peripheral blood from sepsis patients provides significantly more prognostic information than leukocyte counting.
A data-clustering method that incorporates prior knowledge of biological context reveals prognostic signatures of proteomic expression in patients with acute myeloid leukaemia.
This Perspective summarizes the most recent developments in the bioprinting of cartilage, bone and skin for clinical applications, and discusses translational challenges and opportunities in the fabrication of complex 3D-printed tissues and organs.