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A biodegradable probe made of dextran and a urea-based targeting ligand for prostate-specific membrane antigen enables targeted magnetic resonance imaging of tumours expressing the receptor in a xenograft mouse model of prostate cancer.
A method inspired by cryptography maps neural activity to limb movement without requiring the simultaneous collection of neural activity in the motor cortex and of the corresponding physical actions.
A humanized mouse model of X-linked severe combined immunodeficiency suggests that the safety of correcting the human IL2RG gene in haematopoietic stem cells depends on both gene-correction frequency and the conditioning regimen used before cell transplantation.
A computational approach that uses the statistics of movement to find a mapping between neural activity and motor variables decodes the intended movements of monkeys with performance comparable to that of supervised methods.
This Perspective argues that tissue-manufacturing approaches relying on directed self-organization will enable the production of functional tissues with complex biological features.
Optical imaging of fluorescently labelled tissue illuminated by ultraviolet light does not require microscope slides and makes for a rapid alternative to conventional histology.
A slide-free, inexpensive and non-destructive microscopy technique rapidly provides high-resolution histology images that resemble those obtained from conventional haematoxylin-and-eosin-stained specimens.
Prolonged local delivery, via an injectable hydrogel, of a miRNA known to induce cardiomyocyte proliferation stimulates the recovery of mice from myocardial infarction.
An injectable hyaluronic acid hydrogel for the sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in mice after myocardial infarction.
The expression of two DNA repair factors improves the recombination of single-stranded oligodeoxynucleotides with Cas9-induced double-strand breaks, facilitating precise and efficient gene editing.
The DNA mutation that causes Duchenne muscular dystrophy in mice can be corrected, with minimal off-target effects, by gold nanoparticles carrying the CRISPR components.
A theoretical model of chromatin packing heterogeneity predicts patterns in gene expression and can be used to screen for effective chemotherapeutic adjuvants.