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A wearable electrochemical patch for the real-time monitoring of the biomarker C-reactive protein in sweat detects elevated concentrations of the protein in patients with acute or chronic inflammation.
An automated plaque assay leveraging lens-free holographic imaging and deep learning rapidly and accurately detects the cell-lysing events caused by viral replication.
A transformer-based representation-learning model that processes multimodal input in a unified manner outperformed non-unified multimodal models in two clinical diagnostic tasks.
Micropillar patterns causing changes in the nuclear and cellular morphologies of human mesenchymal stromal cells influence the conformation of the cells’ chromatin and their osteogenic differentiation in vitro and in mice.
A nanoparticle integrating a fusion protein of apolipoprotein A1 and interleukin-4 and that targets myeloid-cell-rich haematopoietic organs resolves immunoparalysis in ex vivo and in vivo models of sepsis.
T cells with a chimaeric antigen receptor specific for fluorescein isothiocyanate can be directed against solid tumours via the intratumoural administration of a fluorescein isothiocyanate-conjugated amphiphile that inserts itself in cell membranes.
A representation-learning strategy for machine-learning models applied to medical-imaging tasks improves model robustness and training efficiency and mitigates suboptimal out-of-distribution performance.
Intratumoural heterogeneity can be characterized spatially in patients with liver metastases from colorectal cancer via phenotype-specific multi-view learning models trained with PET–MRI data from mice with subcutaneous colon tumours.
An assay leveraging the target-specific splinted ligation of DNA probes to generate expression cassettes for the cell-free synthesis of reporter proteins accurately detects nucleic acids at ambient temperature.
A high-throughput method leveraging peptide-encoding mRNA barcodes for the in vivo screening of libraries of nanoparticle formulations allows for the rapid optimization of a lipid nanoparticle for the delivery of mRNA to the liver.
Ensembles of explainable machine-learning models increase the quality of explanations for the molecular basis of synergetic drug combinations, as shown for the treatment of acute myeloid leukaemia.
An anti-inflammatory enzyme fused with a tissue-anchoring protein and injected into inflamed tissues ameliorates local inflammation without causing systemic immune suppression, as shown in multiple rodent models of inflammatory diseases.
A method leveraging an integrase-deficient lentivirus, homology-directed repair and the electroporation of a CRISPR-associated ribonucleoprotein complex allows for the knock-in and stable expression of large payloads in primary human cells.
The sensitivity, chemical specificity and spatiotemporal resolution of proton magnetic resonance spectroscopic imaging at 7 T allow for the discrimination of deuterated and non-deuterated neurotransmitters and glucose metabolites in the human brain.
A rapid one-pot isothermal assay that leverages rolling-circle amplification and the endonuclease Cas12a can accurately detect specific miRNAs in extracellular vesicles in patient plasma.
A tether-less and battery-less implant allows for the recording of electroencephalograms, electromyograms and body temperature in freely moving small animals, and for closed-loop neuromodulation via optogenetics and pharmacology.
The throughput of the in vivo screening of hydrogels for antifibrotic properties can be increased by tagging the biomaterials with cells and reading their genotype via next-generation sequencing.
The yields of edited primary human lymphocytes can be increased substantially, with respect to those obtained via electroporation, by delivering a CRISPR ribonucleoprotein alongside an amphiphilic peptide identified via screening.
Durable anti-tumour responses can be triggered by maximizing the cooperative phagocytic potency of macrophages through the disruption of the CD47–SIRPα macrophage checkpoint and by delivering a tumour-opsonizing monoclonal antibody.