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The concurrent depletion of tumour cells and immunosuppressive cells via a monoclonal antibody targeting a common surface marker prevents tumours from acquiring resistance to therapies involving immune checkpoint blockade.
Closed-loop electrical stimulation of the internal capsule of participants undergoing intracranial epilepsy monitoring improved the participants’ performance on a cognitive conflict task, and performance could be decoded from electrode activity.
Efficacious cancer vaccines can be made via the cryogenic silicification of tumour cells followed by the decoration of the silicified surface with pathogen-associated molecular patterns.
Deep surgical wounds can be monitored via conductive multifilament surgical sutures incorporating ‘sensing pledgets’ bearing capacitive sensors operated via harmonic radiofrequency identification.
Multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites.
Monoclonal antibodies conjugated with multiple polymer chains functionalized to target glucose transporter 1 and detaching in the reductive tumour microenvironment augment the potency and safety of checkpoint blockade therapy for glioblastoma.
Lipid nanoparticles can be optimized for the efficient delivery of therapeutic mRNAs to the lung via nebulization, as shown for the delivery of a therapeutic antibody in mice challenged with a lethal dose of the H1N1 influenza A virus.
Orally delivered nanocarriers of insulin or rapamycin made from a polymeric bile acid exert metabolic and immunomodulatory functions, restore blood-glucose levels in mice and pigs with type 1 diabetes, and delay the onset of diabetes in mice.
The loading of two different protein therapeutics onto extracellular vesicles can be optimized by genetically engineering the parent cells, as shown for extracellular vesicles displaying decoy receptors for two pro-inflammatory cytokines.
Brush-like biopolymers mimicking the lubrication properties of natural cartilage-binding complexes in articular joints enhance cartilage regeneration in a rat model of early osteoarthritis.
Injectable and electrically conductive scaffolds displaying shape-memory behaviour and a hierarchical porous structure enhance the functional repair of infarcted heart muscle in rats and minipigs.
Orthogonally conjugating the cytokine interleukin-2 to poly(ethylene glycol) moieties at defined protein sites improves its pharmacokinetics and half-life as well as its therapeutic performance in mouse models of autoimmune diseases.
A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.
In mouse models of hereditary tyrosinaemia and of Leber congenital amaurosis, prime editing can precisely correct the disease-causing mutations, ameliorating the disease phenotypes.
This Review examines classical methods for the preservation of mammalian biospecimens and the associated mechanisms of cryoinjury and discusses how the methods’ applicability limitations are being addressed.