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Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease

Journal of Perinatology volume 36, pages 394–400 (2016)Cite this article

Subjects

Abstract

Objective:

The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status.

Study Design:

Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational age (GA) in preterms, receiving two different nutritional regimens, together with biochemical analysis.

Result:

A total of 234 patients were studied. Newborns with aggressive nutrition had significantly better growth rate and higher values of mc-BTT until discharge. Mc-BTT at day 21 correlates positively with nutritional intakes and phosphatemia; lower limb length positively correlated with mc-BTT (P<0.01). Newborns with low energy intake in the first week of life (<70 kcal kg−1 per day) and low serum phosphate level (<1.4 mmol l−1) at 21 days had lower mc-BTT at 36 weeks of GA (P<0.01).

Conclusion:

Aggressive parenteral intakes in preterms improve growth and bone status in the short-medium term, suggesting that early nutrition could influence bone development.

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Author information

Authors and Affiliations

  1. Women’s and Children’s Health Department, Neonatal Intensive Care Unit, University Hospital of Padova, Padova, Italy

    M Meneghelli, A Pasinato, S Salvadori, P Gaio, M Fantinato, V Vanzo & G Verlato

  2. Laboratory of Clinical Biophysics, IGEA, Modena, Italy

    F De Terlizzi

Authors
  1. M Meneghelli
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  2. A Pasinato
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  3. S Salvadori
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  4. P Gaio
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  5. M Fantinato
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  6. V Vanzo
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  7. F De Terlizzi
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  8. G Verlato
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Correspondence to G Verlato.

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Meneghelli, M., Pasinato, A., Salvadori, S. et al. Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease. J Perinatol 36, 394–400 (2016). https://doi.org/10.1038/jp.2015.212

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  • DOI: https://doi.org/10.1038/jp.2015.212

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