Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Ontiveros, Elgendi et al. devise and validate a machine learning approach that improves the quality of photoplethysmogram signals that can be obtained from video data. This ultimately contributes to advances in non-invasive health monitoring technologies.
Moncla et al. scrutinize the role of circulating proteome in mitral valve prolapse development. Integration conducted on large-scale cross-modality data uncover a causal role of the circulating proteome, immunome and macrophage M2 polarization in mitral valve prolapse.
Abdalla et al. examine how demographic factors shape perceptions of what matters for health across eight countries. They show that high income groups rank genetics as important, urban groups rank healthcare as important, and both low-income groups and non-urban groups rank social support as important.
Wang et al. evaluate the association between adherence to the Life’s Simple 7 lifestyle metrics and cardiometabolic disease (CMD)-free survival in a population of older British men. Men with ideal levels of adherence remained CMD-free for four years longer than those with poor adherence, with physical activity providing the greatest benefit.
Sam et al. describe a case study of a patient with Hodgkin’s lymphoma and papillary carcinoma diagnosed with depletion-associated prolonged acute COVID-19 treated with anti-SARS-CoV-2 the casirivimab-imdevimab monoclonal antibody cocktail. The patient made a full recovery from their persistent infection.
Beaney et al. compare co-occurrence and sequence-based embedding methods and apply graph-based clustering to identify clusters of diseases at multiple resolutions, in over ten million people with multimorbidity. Interpretable clusters of diseases are found that correspond to both established and novel patterns.
Ohannesian, Mallick et al. demonstrate label-free counting and detection of microRNA cargoes for single small extracellular vesicles (sEVs), revealing elevated sEV counts and distinct molecular contents in samples from patients with cancer. Using a simple threshold of sEV count in a blind test, classification of cancer vs. healthy samples is achieved with high sensitivity and specificity.
Yaghmaei et al. utilize doubly robust causal inference estimators and a large medical data set to evaluate the impact of combining Donepezil and Memantine on five-year survival since initial diagnosis of Alzheimer’s disease patients. A significant benefit to survival is seen when the drugs are combined.
Guimbaud et al. use machine learning in a dataset of 1600 European mother-child pairs to link early-life environmental exposures with children’s health. Through the computation of environmental-clinical risk scores, they unveil complex interactions and nonlinear patterns among these factors, underscoring their intricate role in children’s health.
Bryant et al. report findings of a dosimetric analysis of adapted versus non-adapted radiation therapy plans of ultracentral lung lesions treated with ablative stereotactic MRI-guided adaptive radiation therapy. The differences demonstrated help to elucidate the therapeutic window improvements of daily plan adaptation.
Soremekun et al. report the impact of extending seasonal malaria chemoprevention (SMC) to children aged 0–9 years on malaria transmission in the context of a national routine programme. This SMC extension to older children reduces the risk of clinical malaria and asymptomatic infection among adolescents and adults within the same household.
Chen et al. report findings from a phase 1 dose expansion study of the tumor microenvironment modulator VT1021 in patients with solid tumors. VT1021 is found to be safe and tolerable, with preliminary evidence of efficacy and biomarkers of response.
Guo, Zeng, Lu et al. assess SARS-CoV-2 Omicron BA.5 transmission and protection from inactivated vaccines among children and adolescents prior to the end of Zero-COVID measures in Urumqi, China. Two vaccine doses provide improved protection against Omicron infection and reduced transmission versus a single dose when given within the same year.
Sekine et al. traced the origins ofPlasmodium vivax resurgence after achieving malaria elimination on Aneityum Island, Vanuatu. Analyzing five nuclear microsatellite markers, samples from the resurgence and nearby Tanna Island exhibit identical or closely related haplotypes, suggesting that imported infection contributes to the reintroduction.
Tam et al. compare molecular features between adolescents and young adult (AYA) and older adult (OA) patients with soft tissue tumours and identify that components of the spliceosome complex are independent prognostic factors for metastasis free survival in AYA patients.
Van der Zalm et al. apply Ridge regression analysis to RNA-seq data from esophageal cancer samples to predict mesenchymal transitions occurring in patients. Expression of NANOG in pre-treatment biopsies is associated with poor response to neoadjuvant chemoradiation, recurrence, and median overall survival in patients with esophageal adenocarcinoma.
Yan, Liang, Zhang et al. propose a domain knowledge-based interpretable deep learning system to improve breast cancer risk prediction from multimodal ultrasound images. Its inherent interpretability enables effective human-machine collaboration and thus may aid clinical decision-making.
Zhang et al. demonstrate that plasma sampling for a VHL-PROTAC does not represent the tissue concentrations necessary for efficacy; the tissue uptake/retention can be used to guide their therapeutic potential in target organs.
Wever et al. explore the use of different types of patient-friendly material, including urine, for the detection of ovarian cancer by methylation and copy number analysis. Upon continued development, DNA-based testing in cervical scrapes and urine could aid ovarian cancer diagnosis.
James et al. compare mitochondrial function in fibroblast cell lines from disease carriers of spinal muscular atrophy (SMA) and control individuals. They report altered mitochondrial activity in SMA carriers, suggesting that carriers have a subclinical mitochondrial phenotype.