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Alan Herbert discusses the properties of Z-DNA and Z-RNA, interactions with ADAR and other Z-binding proteins, and the role these elements play in disease. He also discusses the implication of Z-forming sites in genome evolution.
Melinda Mills and Charles Rahal discuss genome-wide association studies published in the last 13 years, finding increases in sample sizes, rates of discovery, and traits studied over time. They discuss limitations, including sample diversity, and make recommendations for scientists and funding bodies.
Marco Bürger and Joanne Chory discuss the structural requirements for enzymes carrying out deacetylation reactions for various functions across phyla. They explore how these enzymes have adapted to and achieved specificity on a large number of target molecules.
Tim Koopmans and Yuval Rinkevich review recent findings linking the mesothelium’s embryonic programs that drive epithelial-to-mesenchyme transition with adult pathologies, such as fibrosis, acute scarring, and cancer metastasis. They highlight new avenues for drug development that would target pathways of the mesothelium’s mesenchymal transition.
In honeybees, genotypically identical females develop into queens or sterile workers, depending on their diets. In this review, Ryszard Maleszka discusses the controversial role of the royal jelly protein Royalactin in caste determination and provides a framework for moving beyond the master inducer concept.
