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The article describes the greeting behaviour of elephants and provides an account of first-order intentionality and multicomponent signalling in an animal group other than primates, contributing to our understanding of social signalling in mammals.
A novel method systematically identifies specific biotinylation sites for LC-MS analysis followed by proximity labeling and shows excellent performance compared to related approaches in terms of identification depth with high enrichment power.
Multiomic study reveals that tumor microenvironmental factors such as hypoxia influence intracellular infection of Fusobacterium nucleatum in colorectal cancer cells and provides clues to malignant transformation of infected cells.
Flexible interareal communication mechanism based on realistic spatiotemporal dynamics of propagating waves of neural population activity, showing how modulating this communication explains various neural effects of attention.
Comparison of the bone phenotypes of hyperthyroid versus euthyroid bone cell-specific conditional knockout mice suggests that the osteoblastic, but not osteoclast, BMP receptor BMPR1A is a main driver of hyperthyroidism-associated bone disease.
A study on global arthropod biodiversity dynamics reveals that beta-diversity increased with latitude, distance, and time. Species replacement and richness difference patterns vary across regions, supporting global biodiversity expectations.
A GWAS finds genetic link in ABCC9 gene affecting vocal pitch in both Mandarin and Icelandic speakers, suggesting a shared genetic influence on human vocal systems across populations.
This study focuses on how endothelial cells contribute to ECM accumulation of renal fibrosis and suggests that MDK promotes ACTA2 expression by stabilizing the C/EBPβ protein.
This study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Circular RNA Circ0075305 hinders gastric cancer stem cells by indirectly increasing the expression of RPRD1A. In turn, RPRD1A disrupts TCF4-β-catenin complex formation and promotes downregulation of SOX9 transcription.
This study established a strategy for systemic administration of prodrugs to induce activation in target neurons in the mammalian brain that express Ionotropic Receptors derived from the insect Drosophila melanogaster.
The authors show that the transcription factor E4BP4 mediates the production of anti-inflammatory components that reduce the magnitude of intestinal inflammation in mice.
Pelvimetry and regression analysis show sexual dimorphism in the human fetal pelvis during primary ossification at pelvic inlet, subpubic angle, and the ischial spines’ distance to the transverse diameter of greater pelvis ratio.
Across learning, the brain network transitioned from an integrated state into a segregated state as reflected by an increased modularity value. Replicated across two studies, the speed of the brain state transition was associated with the individual behavioral learning rate.
Human bronchial epithelial cell-derived EVs exhibit immunomodulatory properties through miRNAs & ANXA1, which can suppress NF-κB signaling. The study holds promise as a novel approach for mitigating lung injury and inflammation in acute lung injury.
Golgin45, a Golgi structural protein, is heavily SUMOylated and heat shock stress increases Golgin45 SUMOylation modified by SUMO3 and promotes its inclusion into PML-NBs to transcriptionally regulate lipid metabolism genes.
Efficient phage synthesis yields O157 antigen-specific phages with the detection tag at optimal sites, enabling specific detection of diverse E. coli O157 clinical isolates and suggesting broad applications in bacterial detection and phage therapy.