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This study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
Despite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the microbiome and enhancing propionyl-CoA disposal for gluconeogenesis and fatty acid oxidation to acetyl-CoA.
A MINFLUX tracking study of a truncated kinesin-1 mutant in gently fixed primary rat hippocampal neurons revealed 8 nm substeps and a rotation of its head during the unbound state with nanometer/millisecond resolution
Structural and biochemical analysis of double-stranded RNA transporter SIDT1 reveals the conformational change associated with cholesterol binding and the causal relationship between pH, RNA binding, and ceramidase activity.
This study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
An empirical study of freshwater invertebrates is coupled with a theoretical model of metabolic ecology to show that metabolic plasticity drives species-specific differences in predator-prey interaction rates under warming.
The established HiCASE technique significantly enhances the detection of ultralow frequency mutated genes in ctDNA, promoting its application and translating basic research into clinical practice.
SMG9 deficiency in zebrafish leads to brain abnormalities, cardiac dysfunction, and premature aging due to disrupted nonsense-mediated mRNA decay and increased oxidative stress caused by elevated spermidine oxidase (Smox) levels.
An epitope binning platform based on mammalian cell surface display and DNA sequencing enables the simultaneous binning of multiple antibodies without the need for antibody production and purification.
A biosynthetic gene cluster from a Bacillus strain from the mouse gut produces bacillamide D, a selective cytotoxin, inhibiting growth and motility of human cell lines and murine organoids in vitro.
The analysis of bile acid profiles in biological samples from humans, rats, and mice reveals species-dependent differences as well as sex-dependent differences within each species.
As red wood ant nests age, the arthropod symbiont communities they support undergo a successional shift. This change is marked by a greater degree of specialization and evenness within the community, resulting in increased community stability.
A large-scale analysis of genome-wide association studies links type 2 diabetes with gastrointestinal disorders, implicating causal associations, shared genes and biological pathways.
7-dimensional niche space of 191 primate species shows niche diversity is partitioned unequally. Interspecific competition is lowest in great apes and highest in callitrichids.
Using in vivo two-photon microscopy, the structural dynamics of synapses in the prefrontal cortex of an autism model marmoset were studied. In the marmoset, clustered dendritic spine generation was heightened, which was attenuated by oxytocin.
A study on mice without fast-isoform Myosin Binding Protein C (MyBP-C) suggests that this isoform is a critical determinant of contraction performance via control of sarcomeric motor proteins.
A genome-wide association study in a cohort of 63,992 Danish blood donors identified an association between complete freedom from headache and a locus in the ADARB2 gene. The association was replicated in a cohort of 13,032 Danish blood donors.
The unique structural features of the NopD catalytic domain, an effector protease from symbiotic bacteria rhizobia, grant a surprising versatility to remove various regulatory tags (SUMO, ubiquitin, Nedd8) from host plant proteins.
Structural analysis using cryo-EM reveals that albicin, an inhibitor of the alternative pathway of complement from the saliva of a mosquito, binds the C3bBb complex through contacts with both chains of C3b as well as the protease factor B.
Nesfatin-1 and nesfatin-1-like peptide reduced lipid content in oleic acid-induced HepG2/C3A cells, an effect that was blocked by an AMPK inhibitor compound C. This highlights the therapeutic potential for nesfatin-1 and NLP in lipid disorders.