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A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.
A combination of cell line, transgenic mouse and human genetic data implicates a proinflammatory function of Dickkopf1 across malignant and non-malignant cells.
An attenuated Listeria monocytogenes vectored multiantigenic vaccine is developed, which offers protection against Mycobacterium tuberculosis in mice and guinea pigs.
Readthrough transcripts (RTs) are identified in the genome of Arabidopsis using a long-read sequencing technology and structural and fate examination reveals that RTs are post-transcriptionally regulated by splicing, transcription termination and NMD.
In vitro kinesin-coated gold nanorod (kinesin-GNRs) assays reveal that torque drives both rolling and yawing of kinesin-GNRs translocating along the microtubule axis with possible relevance to intracellular transport.
Next generation sequencing of plant ancient DNA and microscopic evidence from dental calculi of specimens exhumed at Grotta Mora Cavorso (Central Italy) provide insight about the role of edible plants and cultural landscape during early Neolithic.
TIPARP, an inducible poly-ADP-ribose polymerase, is identified as a novel regulator of intraocular pressure through modulation of extracellular matrix and cell cytoskeleton proteins in trabecular meshwork cells.
A secondary (but not primary) dose of the oncolytic virus, VSV, is captured by monocytes and promotes CD8 + T cell recruitment, thereby revealing a mechanism underlying the clinical benefit of repeat dosing in oncolytic virus therapy.
The alternative splicing and genetic variations across the whole MHC-E locus of Rhesus Macaques (Mamu-E) are analysed, which provides a foundation for more comprehensive research of Mamu-E and informs translational research of CMV-based vaccines.
Raman spectroscopy is employed to show simultaneous, label-free imaging of RNA, DNA, and proteins, revealing secondary structural features of intracellular LLPS organelles, and condensed chromosome.
An ensemble encoding approach uses existing individual encoding models with densely-sampled data to predict brain responses to visual stimuli in novel individuals with small amounts of data.
The dynamics of γδ T cell frequencies and functions through the course of SARS-CoV-2 infection in rhesus macaques and African green monkeys reveals that Vδ1 γδ T cells are involved in the early immune response to SARS-CoV-2 infection.
A chromosome-level genome assembly of the American mink (Neogale vison) provides a valuable genetic resource to guide mink breeding strategies and conservation efforts.
EEG measurements of the human motor cortex during a finger tapping task show that premovement cortical oscillatory coupling influences bimanual coordination performance after consolidation.
Behavioral and fMRI experiments using a dot estimation task provide insight into how social interactions create and stabilize perceptual norms as socially shared realities within groups.
EEG measurements in children with Angelman or duplication 15q11.2-13.1 syndrome reveal a dissociation between consciousness and sleep-like spectral content, with complexity-based measures superseding other markers of consciousness.