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The Music frogs are revealed to possess adaptative flexibility under climate changes. Mud nests evolved as a key innovation during perennial high temperatures and precipitations but lost in certain descendants when the weather got dryer and colder.
Genome sequencing of the eastern quoll, an endangered marsupial, describes historical population declines and identifies the likely basis of its colour differences with the closely related Tasmanian devil.
A computational modeling study indicates that relative amount and timing of Ebola virus proteins VP40 and NP drive effective viral particle production.
Tardigrade secretory-abundant heat soluble (SAHS) proteins protect biological structures such as liposomes and microbial cells from dehydration-induced damages, potentially through undergoing structural transition upon desiccation.
Deletion of the ghrelin receptor (GHSR) gene protects against diet-induced obesity and decreases food intake during a high-fat diet in male but not female rats. Inverse agonism of brain GHSR attenuates ghrelin-induced food intake only in male mice.
A meta-analysis of original FSHD transcriptomic data confirms existing knowledge about DUX4 expression and mitochondrial deficits and reveals misregulation of the neuromuscular junction, nuclear envelope, and spliceosome.
The authors present SpatialPrompt, a tool that offers high accuracy and scalability for spot deconvolution and domain identification in spatial transcriptomics, showing superior performance on diverse spatial datasets.
A brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn a challenging new motor skill during six weeks of practice.
Error-prone artificial DNA synthesis (epADS) is presented as an effective method for in vitro generation of genetic diversity for directed evolution of various types of genetic parts, synthetic gene circuits and even microbes.
Annotated structural atlas of cytokines and cytokine receptors featuring hotspots in a unified format, help to understand the mechanisms of cytokine-mediated signal transduction pathways and formulate therapeutic strategies.
This article explores novel routes to better analyze neural processes underlying the brain’s adaptability and cognitive functioning, focusing on executive functions and cognitive control. It delves into the concept of “metacontrol”, proposing a dynamic balance of processes based on situational demands, and discusses the role of different concepts of neural dynamics in supporting adaptive behavior and understanding psychiatric disorders.
The CYR1 mutation can enhance a strain’s thermotolerance and ability to produce high yields of recombinant protein by simultaneously strengthening stress resistance and the energy system through cAMP signalling cascades.
Partially reprogramming a specific population of neurons in the cerebral cortex of mice, improves cognition through greater activation in memory circuits and plasticity induced by the reorganization of the extracellular matrix.
The authors develop a web resource to present pan-cancer mutations in 32 major types of cancer. This new online somatic mutations atlas, OncoDB is publicly available at https://oncodb.org.
fMCI experiments on soft PDMS surfaces and mathematical models suggest that – in the low MPa range – increasing material compliance boosts neuron adhesion, clustering, and communication, impacting tissue engineering and regenerative medicine.
Using metabolomics and proteomics data, the quantity and composition of cellular lipid underwent notable changes in different eff Th cell subsets. Especially, Th17 and iTreg cells enhance glycosphingolipid metabolism to sustain their differentiation.