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EP4 receptor enhances OSCC cell migration through increased Ca2+ signaling, linking to CALML6 and the CaMKK2 pathway. This process promotes mitochondrial function and metastasis, with CaMKK2 emerging as a potential target for OSCC treatment.
This study shows that the soil microbial community and herbivory both influence the assembly of the plant-associated microbial communities, but their effects are generated through different mechanisms.
An orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at the ERα binding site between the PROTAC and a linker metabolite.
An NMR study on the SIB1-WRKY33 interaction identifies the minimal sequence in SIB1 that is essential for complex formation and provides a structural model for understanding how SIB1 regulates the DNA binding activity of WRKY33.
Cryptophyte PSI-CAC structures revealed the differences in protein composition and CAC organization of PSI complex in exponential and stationary growth phases, which might be involved in the binding and energy transfer of lumenal phycobiliproteins.
A field study of coinfection prevalence in water fleas populations revealed strong temporal pattern with prevalence level that don’t differ from random chance, suggests that coinfections in these populations governed by parasite diversity.
MSCs-exo-mediated delivery of miR-1403p ameliorates cognitive impairment in mice with SAE by HMGB1-related microglial pyroptosis and S-lactoylglutathione metabolism.
Developmental changes from birth to 5-years in ASD were associated with a normal physiologic response to chronic excitatory, ATP-related signaling. An inhibitory reversal in this network occurred during typical development that did not occur in ASD.
Piperidine-based ionizable lipids avoid the formation of mRNA–lipid adduct that is responsible for the loss-of-function of mRNA and contribute to the long-term storage stability of mRNA/LNPs as a wet preparation.
This integrative structural biology study elucidates the architecture of the L-A virus at the highest resolution reported to-date. The employed methodology to study yeast cell extracts with minimum perturbation allows exploring protein interactions involved in endogenous virus assembly and function.
Using two-photon fluorescence imaging, the authors show that superoxide anion in hepatic stellate cells impairs the infiltration of CD8+ T cells in a mouse model of hepatocellular carcinoma.
Mathematical models and computer simulations suggest that anti-Hebbian STDP, the type of plasticity observed between cortex and striatum, could support the learning of sequences in the brain.
The article describes the greeting behaviour of elephants and provides an account of first-order intentionality and multicomponent signalling in an animal group other than primates, contributing to our understanding of social signalling in mammals.
A novel method systematically identifies specific biotinylation sites for LC-MS analysis followed by proximity labeling and shows excellent performance compared to related approaches in terms of identification depth with high enrichment power.
Genie, an open-source encoder compliant with ISO/IEC’s MPEG-G standard, delivers state-of-the-art genomic data compression ratios and guarantees long-term data sustainability and decodability through interoperability.
Multiomic study reveals that tumor microenvironmental factors such as hypoxia influence intracellular infection of Fusobacterium nucleatum in colorectal cancer cells and provides clues to malignant transformation of infected cells.
Flexible interareal communication mechanism based on realistic spatiotemporal dynamics of propagating waves of neural population activity, showing how modulating this communication explains various neural effects of attention.
Comparison of the bone phenotypes of hyperthyroid versus euthyroid bone cell-specific conditional knockout mice suggests that the osteoblastic, but not osteoclast, BMP receptor BMPR1A is a main driver of hyperthyroidism-associated bone disease.
A study on global arthropod biodiversity dynamics reveals that beta-diversity increased with latitude, distance, and time. Species replacement and richness difference patterns vary across regions, supporting global biodiversity expectations.