Routes to Reprogramming
The routes taken by cells during reprogramming remain a mystery in many aspects. In this collection, Nature Publishing Group brings together five research articles reporting on efforts to unlock the black box of reprogramming.
Nagy and colleagues have taken an unbiased approach to monitor the diversity of cell states that arise after induction of reprogramming factors expression. They uncovered a novel cell state and analysed the changes in transcriptome, proteome and epigenome associated with reprogramming.
Three news and Comment articles place these findings in perspective with our current knowledge of the molecular mechanisms behind reprogramming. Kerri Smith reflects on the challenges of reprogramming cells to pluripotency with David Cyranoski and Andras Nagy on the Nature podcast.
In this 2014 Online Special on Reprogramming, Nature brought together a selection of articles from Nature Publishing Group that highlights the molecular mechanisms underlying reprogramming and the challenges to efficiently and reliably obtain clinically-relevant cell types.
Eager for more? Keep updated on key developments in reprogramming with content from across nature.com
Image credit: Victoria Summersby/NPG
