Web Focus
Corneal Disease
Corneal and external eye disease is a fascinating sub-specialty of ophthalmology. Dramatic Improvements have occurred in conditions such as the management of keratoconus and dry eye. Compared to retinal diseases, corneal and external diseases have an additional burden of pain as well as visual impairment. They are therefore important to treat. In this web focus we highlight recent publications in Eye which demonstrate innovative approaches to treating corneal diseases.
Cambridge Ophthalmological Symposium Paper
Myopia, an underrated global challenge to vision: where the current data takes us on myopia control FREE
B Holden, P Sankaridurg, E Smith, T Aller, M Jong and M He
Eye 28: 142-146; Published online, 20 December 2013; doi:10.1038/eye.2013.256
The pathogenesis of keratoconus FREE
A E Davidson, S Hayes, A J Hardcastle and S J Tuft
Eye 28: 189-195; Published online, 20 December 2013; doi:10.1038/eye.2013.278
Practical applications to modify and control the development of ametropia FREE
P R Sankaridurg and B A Holden
Eye 28: 134-141; Published online, 06 December 2013; doi:10.1038/eye.2013.255
Surgical strategies to improve visual outcomes in corneal transplantation FREE
M S Rajan
Eye 28: 196-201; Published online, 03 January 2014; doi:10.1038/eye.2013.279
Case Series
Bilateral superior keratoconus: two case reports
G J Rogers and M Attenborough
Eye 28: 1254-1257; Published online, 04 July 2014; doi:10.1038/eye.2014.146
Xerophthalmia—a potential epidemic on our doorstep?
S McLaughlin, J Welch, E MacDonald, S Mantry and K Ramaesh
Eye 28: 621-623; Published online, 14 February 2014; doi:10.1038/eye.2014.17
Clinical Study
Bilateral superior keratoconus: two case reports
G J Rogers and M Attenborough
Eye 28: 1254-1257; Published online, 04 July 2014; doi:10.1038/eye.2014.146
Xerophthalmia—a potential epidemic on our doorstep?
S McLaughlin, J Welch, E MacDonald, S Mantry and K Ramaesh
Eye 28: 621-623; Published online, 14 February 2014; doi:10.1038/eye.2014.17
Intra-lesional 5 fluorouracil for the management of recurrent pterygium FREE
D G Said, L A Faraj, M S Elalfy, A Yeung, A Miri, U Fares, A M Otri, I Rahman, S Maharajan and H S Dua
Eye 27: 1123-1129; Published online, 28 June 2013; doi:10.1038/eye.2013.135
Cicatricial changes in ocular pemphigus FREE
P Chirinos-Saldaña, I Zuñiga-Gonzalez, J C Hernandez-Camarena, A Navas, T Ramirez-Luquin, A Robles-Contreras, M C Jimenez-Martinez, A Ramirez-Miranda, V M Bautista-de Lucio and E O Graue-Hernandez
Eye 28: 459-465; Published online, 31 January 2014; doi:10.1038/eye.2014.3
Cellular changes in tears associated with keratoconjunctival responses induced by nasal allergy FREE
Z Pelikan
Eye 28: 430-438; Published online, 17 January 2014; doi:10.1038/eye.2013.310
Comparison of new motorized injector vs manual injector for implantation of foldable intraocular lenses on wound integrity: an ASOCT study FREE
S Khokhar, R Sharma, B Patil, N Aron and S Gupta
Eye 28: 1174-1178; Published online, 18 July 2014; doi:10.1038/eye.2014.162
Pulsed vs continuous light accelerated corneal collagen crosslinking: in vivo qualitative investigation by confocal microscopy and corneal OCT FREE
C Mazzotta, C Traversi, S Caragiuli and M Rechichi
Eye 28: 1179-1183; Published online, 25 July 2014; doi:10.1038/eye.2014.163
Comparison of the visual outcomes between PRK-MMC and phakic IOL implantation in high myopic patients FREE
H Hashemi, M Miraftab and S Asgari
Eye 28: 1113-1118; Published online, 04 July 2014; doi:10.1038/eye.2014.115
Peripheral hypertrophic subepithelial corneal degeneration presenting with bilateral nasal and temporal corneal changes FREE
M Schargus, C Kusserow, U Schlötzer-Schrehardt, C Hofmann-Rummelt, G Schlunck and G Geerling
Eye 29: 88-97; Published online, 03 October 2014; doi:10.1038/eye.2014.236
Increased systemic oxidative stress in patients with keratoconus FREE
I Toprak, V Kucukatay, C Yildirim, E Kilic-Toprak and O Kilic-Erkek
Eye 28: 285-289; Published online, 06 December 2013; doi:10.1038/eye.2013.262
Sterile keratitis after combined riboflavin-UVA corneal collagen cross-linking for keratoconus FREE
F C Lam, P Geourgoudis, M A Nanavaty, S Khan and D Lake
Eye 28: 1297-1303; Published online, 08 August 2014; doi:10.1038/eye.2014.173
Effects and adverse events after CXL for keratoconus are independent of age: a 1-year follow-up study FREE
P B Baenninger, L M Bachmann, L Wienecke, C Kaufmann and M A Thiel
Eye 28: 691-695; Published online, 14 March 2014; doi:10.1038/eye.2014.56
Factors affecting outcomes of corneal collagen crosslinking treatment FREE
I Toprak, V Yaylalı and C Yildirim
Eye 28: 41-46; Published online, 18 October 2013; doi:10.1038/eye.2013.224
Surgical management of corneal limbal dermoids: retrospective study of different techniques and use of Mitomycin C FREE
S J Lang, D Böhringer and T Reinhard
Eye 28: 857-862; Published online, 23 May 2014; doi:10.1038/eye.2014.112
Retrospective contralateral study comparing Descemet membrane endothelial keratoplasty with Descemet stripping automated endothelial keratoplasty FREE
A-KB Maier, E Gundlach, J Gonnermann, M K J Klamann, E Bertelmann, P W Rieck, A M Joussen and N Torun
Eye 29: 327-332; Published online, 21 November 2014; doi:10.1038/eye.2014.280
In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms: a pilot study FREE
Y Qazi, A Kheirkhah, C Blackie, A Cruzat, M Trinidad, C Williams, D R Korb and P Hamrah
Eye 29: 1099-1110; Published online, 19 June 2015; doi:10.1038/eye.2015.103
Evaluation of corneal endothelial cell damage after vitreoretinal surgery: comparison of different endotamponades FREE
E Cinar, M O Zengin and C Kucukerdonmez
Eye 29: 670-674; Published online, 13 March 2015; doi:10.1038/eye.2015.26
Periodic acid–Schiff staining demonstrates fungi in chronic anterior blepharitis FREE
Z Dadaci, F Kılınç, T T Ozer, G O Sahin, N O Acir and M Borazan
Eye 29: 1522-1527; Published online, 21 August 2015; doi:10.1038/eye.2015.144
Outcome of complete intrastromal ring implantation using femtosecond laser in pellucid marginal degeneration FREE
M Jabbarvand, H Hashemian, M Khodaparast, F Bazvand and A Beheshtnejad
Eye 29: 783-790; Published online, 27 March 2015; doi:10.1038/eye.2015.33
The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye FREE
B E Kurtul, P A Özer and M S Aydinli
Eye 29: 1081-1084; Published online, 12 June 2015; doi:10.1038/eye.2015.96
Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications FREE
M Saini, R Dhiman, T Dada, R Tandon and M Vanathi
Eye 29: 808-814; Published online, 10 April 2015; doi:10.1038/eye.2015.40
Prevalence of gonococcal conjunctivitis in adults and neonates FREE
L McAnena, S J Knowles, A Curry and L Cassidy
Eye 29: 875-880; Published online, 24 April 2015; doi:10.1038/eye.2015.57
Corneal collagen crosslinking for keratoconus or corneal ectasia without epithelial debridement FREE
N Hirji, E Sykakis, F C Lam, R Petrarca, S Hamada and D Lake
Eye 29: 764-768; Published online, 20 March 2015; doi:10.1038/eye.2015.23
Endothelial cell loss and complication rates with combined Descemets stripping endothelial keratoplasty and cataract surgery in a UK centre FREE
S M Jones, M A Fajgenbaum and E J Hollick
Eye 29: 675-680; Published online, 13 March 2015; doi:10.1038/eye.2015.30
Deep anterior lamellar keratoplasty—triple procedure: a useful clinical application of the pre-Descemet’s layer (Dua’s layer) FREE
A A Zaki, M S Elalfy, D G Said and H S Dua
Eye 29: 323-326; Published online, 31 October 2014; doi:10.1038/eye.2014.273
Effect of chronic anti-glaucoma medications and trabeculectomy on tear osmolarity FREE
S-Y Lee, T T Wong, J Chua, C Boo, Y F Soh and L Tong
Eye 27: 1142-1150; Published online, 12 July 2013; doi:10.1038/eye.2013.144
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane FREE
J Yang, F-h Yang, C-H Peng, D Erol, S H Tsang and X-r Li
Eye 27: 1254-1262; Published online, 16 August 2013; doi:10.1038/eye.2013.161
Presoaking with BSS used for thin manually dissected DSEK (TMDSEK): a viable option for thin DSEK FREE
M Tsatsos, A Konstantopoulos, P Hossain and D Anderson
Eye 28: 701-704; Published online, 14 March 2014; doi:10.1038/eye.2014.36
Macular corneal dystrophy and associated corneal thinning FREE
L Dudakova, M Palos, M Svobodova, J Bydzovsky, L Huna, K Jirsova, A J Hardcastle, S J Tuft and P Liskova
Eye 28: 1201-1205; Published online, 01 August 2014; doi:10.1038/eye.2014.164
Flap characteristics, predictability, and safety of the Ziemer FEMTO LDV femtosecond laser with the disposable suction ring for LASIK FREE
J Pietilä, A Huhtala, P Mäkinen and H Uusitalo
Eye 28: 66-71; Published online, 15 November 2013; doi:10.1038/eye.2013.244
Pneumodescemetopexy with perfluoroethane (C2F6) for the treatment of acute hydrops secondary to keratoconus FREE
D SJ Ting and S Srinivasan
Eye 28: 847-851; Published online, 16 May 2014; doi:10.1038/eye.2014.109
Ocular residual astigmatism’s effect on high myopic astigmatism LASIK surgery FREE
M A Teus, C Arruabarrena, J L Hernández-Verdejo, R Cañones and D G Mikropoulos
Eye 28: 1014-1019; Published online, 27 June 2014; doi:10.1038/eye.2014.133
Matched optical quality comparison of 3-year results of PRK–MMC and phakic IOL implantation in the correction of high myopia FREE
M Miraftab, H Hashemi and S Asgari
Eye 29: 926-931; Published online, 15 May 2015; doi:10.1038/eye.2015.71
Three percent diquafosol ophthalmic solution as an additional therapy to existing artificial tears with steroids for dry-eye patients with Sjögren’s syndrome FREE
N Yokoi, Y Sonomura, H Kato, A Komuro and S Kinoshita
Eye 29: 1204-1212; Published online, 10 July 2015; doi:10.1038/eye.2015.125
Clinical outcomes between optical path difference custom aspheric treatment and optimized prolate ablation photorefractive keratectomy in myopia exceeding 8 diopters FREE
B J Choi, Y M Park and J S Lee
Eye 29: 356-362; Published online, 14 November 2014; doi:10.1038/eye.2014.272
Acute corneal hydrops in keratoconus: a national prospective study of incidence and management FREE
A Barsam, H Petrushkin, N Brennan, C Bunce, W Xing, B Foot and S Tuft
Eye 29: 469-474; Published online, 16 January 2015; doi:10.1038/eye.2014.333
Rituximab for the treatment of IgG4-related orbital disease: experience from five cases FREE
A Wu, N H Andrew, A Tsirbas, P Tan, A Gajdatsy and D Selva
Eye 29: 122-128; Published online, 24 October 2014; doi:10.1038/eye.2014.251
Correspondence
Complete dehiscence of a DALK graft after early suture removal FREE
N Padrón-Pérez, A Filloy and T Martí-Huguet
Eye 28: 909-911; Published online, 04 April 2014; doi:10.1038/eye.2014.59
Femtosecond-assisted intrastromal corneal cross-linking for early and moderate keratoconus FREE
M Balidis, V E Konidaris, G Ioannidis and A J Kanellopoulos
Eye 28: 1258-1260; Published online, 25 July 2014; doi:10.1038/eye.2014.155
Localized peripheral primitive neuroectodermal tumor of the conjunctiva: a rare presentation FREE
H-M Chen, W-Y Chuang, H-Y Chu and H-Y Tan
Eye 28: 1143-1144; Published online, 30 May 2014; doi:10.1038/eye.2014.120
Intrastromal corneal rings and corneal collagen crosslinking for progressive keratoconus: comparison of two sequences FREE
N Saib, S Bonnel, J-R Fenolland, M Abrieu, C Rambaud, M Berguiga, F Froussart-Maille and J-C Rigal-Sastourne
Eye 29: 294-295; Published online, 05 December 2014; doi:10.1038/eye.2014.285
‘Double occlusion’: black Artisan iris claw intraocular lens insertion following failed occlusion treatment for intractable diplopia FREE
O Shonibare and J Lochhead
Eye 28: 768-769; Published online, 28 March 2014; doi:10.1038/eye.2014.68
Amlodipine as a cause of mucous membrane pemphigoid: first report of amlodipine as a causative agent in MMP FREE
G S Williams, R Goodwin and D Hughes
Eye 27: 1425-1425; Published online, 06 September 2013; doi:10.1038/eye.2013.197
Perfluropropane (C3F8) gas injection followed by deep anterior lamellar keratoplasty (DALK) in severe keratoconus FREE
N Narayan and M S Sridhar
Eye 28: 1260-1261; Published online, 18 July 2014; doi:10.1038/eye.2014.159
Intradescemetic air trap post deep anterior lamellar keratoplasty in a child with mucopolysaccharidosis FREE
R Arora, D Gupta, P Jain, G Goyal, Y Goel and J L Goyal
Eye 28: 495-496; Published online, 07 February 2014; doi:10.1038/eye.2014.5
Can breast implants be responsible for dry eye? FREE
C Virevialle, A Labbé, S Dupont-Monod, F Parent and C Baudouin
Eye 28: 633-634; Published online, 07 March 2014; doi:10.1038/eye.2014.6
Sterile postoperative endophthalmitis following HOYA IOL insertion FREE
N Kumaran, G Larkin and E J Hollick
Eye 28: 1382-1382; Published online, 25 July 2014; doi:10.1038/eye.2014.170
Spontaneous resolution of a rare case of circumferential lymphangiectasia haemorrhagica conjunctivae FREE
V Huerva, A E Traveset, F J Ascaso and M C Sánchez
Eye 28: 912-914; Published online, 04 April 2014; doi:10.1038/eye.2014.73
Efficacy and safety of patching vs bandage lens on postoperative pain following pterygium surgery FREE
S N Yeung, A Lichtinger, P Kim, U Elbaz, J Y F Ku, J C Teichman, M D Amiran and A R Slomovic
Eye 29: 295-296; Published online, 05 December 2014; doi:10.1038/eye.2014.286
Laboratory Study
Potential pharmacokinetic role of organic cation transporters in modulating the transcorneal penetration of its substrates administered topically FREE
J Nirmal, S B Singh, N R Biswas, V Thavaraj, R V Azad and T Velpandian
Eye 27: 1196-1203; Published online, 12 July 2013; doi:10.1038/eye.2013.146
Double port injector device to reduce endothelial damage in DMEK FREE
F Arnalich-Montiel, F J Muñoz-Negrete and M P De Miguel
Eye 28: 748-751; Published online, 28 March 2014; doi:10.1038/eye.2014.67
Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study FREE
J Ye, Y-F Xu, L-X Lou, K Jin, Q Miao, X Ye and Y Xi
Eye 29: 964-971; Published online, 08 May 2015; doi:10.1038/eye.2015.62
Quantification of allospecific and nonspecific corneal endothelial cell damage after corneal transplantation FREE
S K Chauhan, U Jurkunas, T Funaki, M Dastjerdi and R Dana
Eye 29: 136-144; Published online, 17 October 2014; doi:10.1038/eye.2014.248
Review
Keratoglobus FREE
B S Wallang and S Das
Eye 27: 1004-1012; Published online, 28 June 2013; doi:10.1038/eye.2013.130
Pattern recognition receptors in microbial keratitis FREE
M-A Taube, M del Mar Cendra, A Elsahn, M Christodoulides and P Hossain
Eye 29: 1399-1415; Published online, 10 July 2015; doi:10.1038/eye.2015.118
Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus FREE
Z Shalchi, X Wang and M A Nanavaty
Eye 29: 15-29; Published online, 03 October 2014; doi:10.1038/eye.2014.230
Neuropathic ocular pain: an important yet underevaluated feature of dry eye FREE
A Galor, R C Levitt, E R Felix, E R Martin and C D Sarantopoulos
Eye 29: 301-312; Published online, 07 November 2014; doi:10.1038/eye.2014.263
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