Vaso-occlusive disorders
The occlusion of a blood vessel can manifest with a variety of symptoms, which depend on the location and type (artery or vein) of the affected vessel, among other factors. In addition, vaso-occlusion can result from several pathophysiological mechanisms, and the underlying aetiology contributes to guide management. Anticoagulant drugs are used for the prevention and treatment of thrombotic diseases, but at the cost of increased risk of bleeding. This delicate cost-benefit balance drives intense research into novel agents, both anticoagulants and antidotes to reverse their effects (for example, see this article in Nature Medicine).
This collection presents a selection of Primers and PrimeViews published in Nature Reviews Disease Primers on conditions that are commonly associated with vaso-occlusion, and includes an animation describing the risk factors, mechanisms and treatment of pulmonary embolism.
This Collection is editorially independent, produced with financial support from a third party. About this content.
Nature Research is pleased to acknowledge the financial support of Portola Pharmaceuticals in making the Primers in this collection freely available for 6 months (until 13th June 2019) and in production of the animation on pulmonary embolism. The sponsor retains sole responsibility for the following message.
Portola is a biopharmaceutical company focused on the development and commercialization of novel therapeutics in the areas of thrombosis, other hematologic disorders and inflammation for patients who currently have limited or no approved treatment options.
We are advancing our three wholly-owned compounds using novel biomarker and genetic approaches that may increase the likelihood of clinical, regulatory and commercial success of our potentially life-saving therapies. Two of these compounds were discovered through our internal research efforts and one was discovered by Portola scientists during their time at a prior company.
For more information, visit http://www.portola.com
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