Heart regeneration and beyond

This Collection seeks to shape our field’s understanding of cardiac regeneration today with a broad scope of research and translational studies to inspire ongoing efforts to create novel treatments for a diverse population of cardiac patients. Primary research studies are highly encouraged in the three currently conceptualized areas of heart regeneration – cardiomyocyte transplantation, proliferation, and direct reprogramming – and especially encouraged from innovative conceptual approaches targeting fibrosis and remodeling, sarcomere and myocyte structure and function, immune and inflammation modulation, metabolic syndrome and metabolism, ischemia and neuropathy, and inherited disease. Studies showcasing the highest level of rigor from molecular, cellular, surgical, and drug based interventions to gene therapy and tissue engineering are of interest, requiring power analyses for sample size for all in vitro and in vivo preclinical and clinical research (no case studies). Review articles, commentaries, and editorials that fall within the scope and aims of this Collection are considered for inclusion, for example, those that may address current challenges in biomanufacturing, regulatory considerations, and strategies for patient selection and therapy delivery. The global epidemic of cardiovascular disease, from atrial fibrillation to heart failure, requires global scientific cooperation upheld by integrity and striving to make real impact for patients, as this Collection aims to facilitate for heart regeneration and beyond.

This Collection supports and amplifies research related to SDG 3.