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Nature Portfolio is launching a new open Collection to call for submissions on immune aging, and encourages submissions of primary research studying related topics, including but not limited to cellular and molecular, mechanistic analyses using animal, human or non-human primate models. We welcome new insights on both of the innate and adaptive immune systems, as well as their crosstalk in relevant settings. In parallel, we are also interested in under-represented groups or cohorts even with exploratory outcomes, and appreciate broad contexts such as infection, cancer and autoimmunity. Finally, we may consider Review articles but primary research will be the main priority in this Collection.