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Scaffolds used in tissue engineering must meet a complex set of requirements. They must simulate the function of the compromised tissue, provide a favorable environment for the formation of new tissue, and decompose once their role is fulfilled. For tissue regeneration to be successful, scaffolds must therefore have specific physical, mechanical and chemical properties. They must also be biocompatible, and are often seeded with cells or bioactive molecules to promote tissue growth. Successfully meeting these requirements is essential for effective tissue repair.
This cross-journal Collection between Nature Communications, Communications Materials and Scientific Reports brings together the latest developments in scaffolds for hard and soft tissue regeneration. Topics of interest include, but are not limited to, the following:
All classes of biomaterials for scaffolds
Controlling scaffold architecture and surface properties
Optimizing scaffold properties and function
Mechanistic understanding, including cell-scaffold interactions and cell behavior
Design and manufacturing approaches
In-vitro and in-vivo demonstrations of functionality
We welcome the submission of all papers relevant to biomaterial scaffolds for tissue engineering. Nature Communications and Communications Materials will publish research papers, Reviews and Perspectives, and Scientific Reports will publish research papers. All submissions will be subject to the same review process and editorial standards as regular submissions at the participating journals.
Infected bone defects are a major challenge in orthopedic treatment. Here, the authors develop an electroactive mineralized scaffold that achieves nearly complete in situ healing of infected bone in rats, rabbits and beagle dogs.
The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment.
Current limb salvage techniques for the treatment of the osteopathic non-unions still have several drawbacks that may prolong the duration of treatment. Here, Lin et al., propose using an osteoinductive (BMP-2 eluting) intramedullary and biodegradable implant to achieve early bony bridging and show that pin tract infection or docking site non-union can be avoided in experimental animal models of large bone defects.
Minimally invasive implants have potential in treating intervertebral disc degeneration, but providing sufficient mechanical support is challenging. Here, the authors report the development of a nucleus pulposus scaffold, with properties designed to match those of native nucleus pulposus.