Nobel Prize in Physiology or Medicine 2021
The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch." Their research identified transient receptor potential (TRP) and PIEZO ion channels as the proteins that sense these ubiquitous stimuli. To celebrate the award Nature Portfolio presents a Collection including publications from the winners, essential reviews on the topic, and further exciting research focused on different aspects of TRP and PIEZO channels and their roles in physiology and disease
Grünenthal is a global leader in pain management. As a science-based, privately-owned pharmaceutical company, we have a long track record of bringing innovative treatments to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focusing all of our activities and efforts on moving towards our vision of a world free of pain.
Grünenthal strives to create better pain medicines by leveraging, amongst others, the Nobel Prize-winning TRPV1 research. A tangible outcome of this research is a topically applied non-opioid therapy that delivers capsaicin (a potent TRPV1 receptor agonist) directly to the TRPV1 expressing nociceptors in the skin. Consequently, these nerves defunctionalize, resulting in long-lasting pain relief. Additionally, an ongoing Phase III program will investigate the potential of Resiniferatoxin, another TRPV1 agonist, for the treatment of pain associated with osteoarthritis of the knee.
You can find out more about Grünenthal at https://www.grunenthal.com/.
