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Cancer cells exist in a complex microenvironment consisting of vasculature, stromal- and immune cells and extracellular matrix (ECM). The reciprocal and dynamic interactions between cells and between cells and the ECM contributes to cancer evolution and heterogeneity. Conversely, the tumour remodels its environment to avoid elimination by the immune response. The tumour microenvironment (TME) can possess tumour-antagonising or tumour-promoting functions and impact on cancer therapies.
Communications Biology now invites articles exploring this important area. We will consider articles that provide insights into the cellular and molecular mechanisms and signalling components underlying the interplay between tumours and their microenvironment, as well as how these interactions impact on cancer therapy.
Alongside original research Articles, we will also consider Reviews, Perspectives and Comments covering these topics. All submissions will be subject to the same review process as regular Communications Biology Articles.
This Collection supports and amplifies research related to SDG 3.
Single-cell profiling of primary and bone metastatic renal cell carcinoma suggests variation in intratumoral heterogeneity between samples and the is a valuable resource for examining the underlying pathogenic mechanisms for these cancers.
A scRNA-seq study reveals a complex yet unique tumor microenvironment of laryngeal squamous cell carcinoma (LSCC) with lymphatic metastasis, and the data may help identify potential diagnostic biomarkers and therapeutic targets for LSCC.