The greatly improved prediction of protein 3D structure from sequence achieved by the second version of AlphaFold in 2020 has already had a huge impact on biological research, but challenges remain; the protein folding problem cannot be considered solved. We expect fierce competition to improve the method even further and new applications of machine learning to help illuminate proteomes and their many interactions.
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Acknowledgements
The authors acknowledge help from R. Laskowski, who generated Fig. 3. J.M.T. acknowledges funding from EMBL.
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Jones, D.T., Thornton, J.M. The impact of AlphaFold2 one year on. Nat Methods 19, 15–20 (2022). https://doi.org/10.1038/s41592-021-01365-3
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DOI: https://doi.org/10.1038/s41592-021-01365-3
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