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Prospects and challenges for FAIR toxicogenomics data

Nature Nanotechnology volume 17, pages 17–18 (2022)Cite this article

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Matters Arising to this article was published on 23 December 2021

The Original Article was published on 20 May 2021

arising from Nina Jeliazkova et al. Nature Nanotechnology https://doi.org/10.1038/s41565-021-00911-6 (2021)

The article by Jeliazkova at al.1 recently published in this journal addresses the pivotal topic of data sharing and reuse in nanosafety. Current research in the field is highly multidisciplinary, as described also in the recent call for reporting standards for bio–nano experimental studies2. Hence, the application of the general FAIR (findable, accessible, interoperable and reusable) principles3, although valid, might fall short when considering field-specific needs and requirements. This is especially true for toxicogenomics, in which additional challenges are posed by the articulated data analytics as well as the need to integrate multiple datasets to increase the statistical power and domain of applicability of the resulting predictive models. These limitations substantially affect the possibility of including toxicogenomics-based evidence in safe-by-design protocols as well as in regulatory hazard and risk decisions.

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Acknowledgements

We acknowledge funding from the European Union’s Horizon 2020 research and innovation programme via the NanoSolveIT Project (grant agreement no. 814572) and the Academy of Finland (grant agreement no. 322761).

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Authors and Affiliations

  1. Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

    Laura A. Saarimäki & Dario Greco

  2. Nanoinformatics Department, NovaMechanics Ltd, Nicosia, Cyprus

    Georgia Melagraki & Antreas Afantitis

  3. School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK

    Iseult Lynch

  4. Institute of Biotechnology, University of Helsinki, Helsinki, Finland

    Dario Greco

Authors
  1. Laura A. Saarimäki
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  2. Georgia Melagraki
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  3. Antreas Afantitis
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  4. Iseult Lynch
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  5. Dario Greco
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Contributions

L.A.S. carried out the formal analysis, contributed to the data curation and methodology, and co-wrote the original draft. G.M. contributed to the methodology, review and editing. A.A. contributed to the methodology, review and editing, and funding acquisition. I.L. contributed to the data curation and funding acquisition, and co-wrote the original draft. D.G. conceptualized and supervised the work, contributed to the funding acquisition and co-wrote the original draft.

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Correspondence to Dario Greco.

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The authors declare no competing interests.

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Saarimäki, L.A., Melagraki, G., Afantitis, A. et al. Prospects and challenges for FAIR toxicogenomics data. Nat. Nanotechnol. 17, 17–18 (2022). https://doi.org/10.1038/s41565-021-01049-1

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