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Data availability
Data used in this study are publicly available from the TCGA database (https://portal.gdc.cancer.gov/).
References
Islami F, Poustchi H, Pourshams A, Khoshnia M, Gharavi A, Kamangar F, et al. A prospective study of tea drinking temperature and risk of esophageal squamous cell carcinoma. Int J Cancer. 2020;146:18–25.
Yu C, Tang H, Guo Y, Bian Z, Yang L, Chen Y, et al. Hot Tea consumption and its interactions with alcohol and tobacco use on the risk for esophageal cancer: a population-based cohort study. Ann Intern Med. 2018;168:489–97.
Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, et al. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Br J Cancer. 2022;127:1424–39.
Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12:453–7.
Kojima I, Nagasawa M. TRPV2. Handb Exp Pharm. 2014;222:247–72.
Siveen KS, Nizamuddin PB, Uddin S, Al-Thani M, Frenneaux MP, Janahi IA, et al. TRPV2: a cancer biomarker and potential therapeutic target. Dis Markers. 2020;2020:8892312.
Santoni G, Farfariello V, Liberati S, Morelli MB, Nabissi M, Santoni M, et al. The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses. Front Immunol. 2013;4:34.
Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, Caterina MJ. TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol. 2010;11:232–9.
Cahalan MD, Chandy KG. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009;231:59–87.
Acknowledgements
We would like to thank Sangerbox (http://vip.sangerbox.com/) for the support of data visualisation.
Funding
This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS) (No. 2021-I2M-C&T-B-018).
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HY and YL were involved in conceptualising, literature review and drafting the letter, and YM revised the letter for final submission. All authors approved the final version for submission and publication of the content.
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Yi, H., Lin, Y., Wang, X. et al. Pan-cancer analysis of TRPV2 identifies its potential role as a prognostic and immunologic biomarker in oesophageal cancer. Br J Cancer 129, 567–569 (2023). https://doi.org/10.1038/s41416-023-02302-1
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DOI: https://doi.org/10.1038/s41416-023-02302-1