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Clinical Studies

Reply to comment(s) on “Development and validation of a novel strong prognostic index for colon cancer through a robust combination of laboratory features for systemic inflammation: a prognostic immune nutritional index”

British Journal of Cancer volume 127, pages 170–171 (2022)Cite this article

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We have read constructive comments by Xie et al. [1] regarding our study recently published in Br J Cancer [2].

In our study [2], to compare the prognostic markers’ performance, we calculated the continuous net reclassification index (NRI) and its 95% confidence interval (CI) value through the bootstrapping method. Although we observed that 95% CI values of NRIs did not overlap with zero, we understand that the absence of a statistical value may confuse the readers in effectively reviewing the comparisons.

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Data availability

The datasets generated during and/or analysed during this study are not publicly available but are available from the corresponding author on reasonable request.

References

  1. Xie H, Ge Y, Shi H. Comment on: “Development and validation of a novel strong prognostic index for colon cancer through a robust combination of laboratory features for systemic inflammation: a prognostic immune nutritional index”. Br J Cancer (this issue).

  2. Jung SH, Hao J, Shivakumar M, Nam Y, Kim J, Kim MJ, et al. Development and validation of a novel strong prognostic index for colon cancer through a robust combination of laboratory features for systemic inflammation: a prognostic immune nutritional index. Br J Cancer. 2022. https://doi.org/10.1038/s41416-022-01767-w

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Funding

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1F1A1063000).

Author information

Authors and Affiliations

  1. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sang-Hyuk Jung, Dokyoon Kim & Ji Won Park

  2. Department of Digital Health, SAIHST, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea

    Sang-Hyuk Jung

  3. Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA

    Dokyoon Kim

  4. Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea

    Ji Won Park

  5. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Ji Won Park

Authors
  1. Sang-Hyuk Jung
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  2. Dokyoon Kim
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  3. Ji Won Park
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Contributions

S-HJ drafted the first version of the letter. DK and JWP edited the manuscript. All authors have approved the final version of the manuscript.

Corresponding authors

Correspondence to Dokyoon Kim or Ji Won Park.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Institutional Review Board (no. 2101-042-1187, NCC2021-0057).

Competing interests

The authors declare no competing interests.

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Jung, SH., Kim, D. & Park, J.W. Reply to comment(s) on “Development and validation of a novel strong prognostic index for colon cancer through a robust combination of laboratory features for systemic inflammation: a prognostic immune nutritional index”. Br J Cancer 127, 170–171 (2022). https://doi.org/10.1038/s41416-022-01862-y

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  • DOI: https://doi.org/10.1038/s41416-022-01862-y

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