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References
Luznik L, O’Donnell PV, Symons HJ, Chen AR, Leffell MS, Zahurak M, et al. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transpl. 2008;14:641–50. https://doi.org/10.1016/j.bbmt.2008.03.005.
Bolaños-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, et al. Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis. N Engl J Med. 2023;388:2338–48. https://doi.org/10.1056/NEJMoa2215943.
Spitzer TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transpl. 2001;27:893–8. https://doi.org/10.1038/sj.bmt.1703015.
ElGohary G, Toor AA, Gergis U. Engraftment syndrome after allogeneic stem cell transplantation: a systematic review and meta-analysis. Bone Marrow Transpl. 2023;58:1–9. https://doi.org/10.1038/s41409-022-01849-6.
İleri T, Ünal İnce E, Çakmaklı H, Uysal Z, Gençtürk Z, Ertem M. Evaluation of engraftment syndrome in children following full-matched related donor hematopoietic stem cell transplantations. Pediatr Transpl. 2016;20:581–9. https://doi.org/10.1111/petr.12708.
Omer AK, Kim HT, Yalamarti B, McAfee SL, Dey BR, Ballen KK, et al. Engraftment syndrome after allogeneic hematopoietic cell transplantation in adults. Am J Hematol. 2014;89:698–705. https://doi.org/10.1002/ajh.23716.
Carreras E, Diaz-Ricart M. The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transpl. 2011;46:1495–502. https://doi.org/10.1038/bmt.2011.65.
Gorak E, Geller N, Srinivasan R, Espinoza-Delgado I, Donohue T, Barrett AJ, et al. Engraftment syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation: incidence and effects on survival. Biol Blood Marrow Transpl. 2005;11:542–50. https://doi.org/10.1016/j.bbmt.2005.04.009.
Pagliuca S, Michonneau D, Sicre de Fontbrune F, Sutra Del Galy A, Xhaard A, Robin R, et al. Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. Blood Adv. 2019;3:2424–35. https://doi.org/10.1182/bloodadvances.2019000143.
Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG. Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression. J Clin Invest. 2019;129:2357–73. https://doi.org/10.1172/JCI12421.
Spitzer TR. Engraftment syndrome: double-edged sword of hematopoietic cell transplants. Bone Marrow Transpl. 2015;50:469–75. https://doi.org/10.1038/bmt.2014.296.
Tecchio C, Cassatella MA. Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation. Cell Mol Immunol. 2021;18:905–18. https://doi.org/10.1038/s41423-020-00581-9.
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TRS conceived the idea for the study. DJI and KC collected study data, and DJI performed the statistical analyses. DJI, TRS, and ZD wrote the first draft of the paper. YC, BRD, AE, MJF, MBL, SLM, RAN, and PVO provided critical feedback on the paper, and all authors approved the final version of the paper.
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Y-BC: Consulting for Incyte, Takeda, Magenta, Celularity, Novo Nordisk, and Astellas. Matthew JF: Consulting: Kite, Novartis, BMS, Iovance. Research: Arcellx, Novartis, Kite. Richard A. Newcomb: Equity was received from Timedoc in 2022 and 2023; the relationship now ended. Spouse equity received from Vertex Pharmaceuticals; relationship ongoing. Thomas R Spitzer: Bluebird Bio (Data Monitoring Committee), Ossium Health (Scientific Review Committee), Qihan Biotech (Scientific Advisory Board), Syneos Health (Data Monitoring and Adjudication Committees).
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Ikeda, D.J., DeFilipp, Z., Collier, K. et al. Low incidence of engraftment syndrome following allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide. Bone Marrow Transplant 59, 131–133 (2024). https://doi.org/10.1038/s41409-023-02123-z
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DOI: https://doi.org/10.1038/s41409-023-02123-z