HA-35 kDa strengthens the epithelial barrier by altering tight junction expression and reducing bacterial translocation in murine NEC. HA-35kDa could also protect against NEC by enhancing antimicrobial peptide production, thereby altering the intestinal microbial milieu, and by negatively regulating TLR4 signaling.1
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Gunasekaran, A. et al. Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis. Pediatr. Res. https://doi.org/10.1038/s41390-019-0563-9 (2019).
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Gunasekaran, A., Eckert, J., Burge, K. et al. Insights Image for “Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis”. Pediatr Res 87, 1272 (2020). https://doi.org/10.1038/s41390-020-0773-1
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DOI: https://doi.org/10.1038/s41390-020-0773-1
