Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

There is not much to mediate [yet] when it comes to diet and depression

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K, et al. Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry. 2021;26:134–50.

  2. Booij L, van der Does W, Riedel WJ. Monoamine depletion in psychiatric and healthy populations. Mol Psychiatry. 2003;8:951–73.

    Article  CAS  Google Scholar 

  3. Thomas-Odenthal F, Molero P, van der Does W, Molendijk M. Impact of review method on the conclusions of clinical reviews: a systematic review on dietary interventions in depression as a case in point. PloS One. 2020;15:e0238131.

    Article  CAS  Google Scholar 

  4. Molendijk ML, Fried EI, Van der Does W. The SMILES trial: do undisclosed recruitment practices explain the remarkably large effect? BMC Med. 2018;16:1–3.

    Article  Google Scholar 

  5. Lassale C, Batty GD, Baghdadli A, Jacka F, Sánchez-Villegas A, Kivimäki M, et al. Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Mol Psychiatry. 2019;24:965–86.

    Article  Google Scholar 

  6. Molendijk M, Molero P, Sánchez-Pedreño FO, van der Does W, Martínez-González MA. Diet quality and depression risk: a systematic review and dose-response meta-analysis of prospective studies. J Affect Disord. 2018;226:346–54.

    Article  Google Scholar 

  7. Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA. 2008;105:17046–9.

    Article  CAS  Google Scholar 

  8. Karege F, Perret G, Bondol G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109:143–8.

    Article  CAS  Google Scholar 

Download references

Funding

This project was funded through continued support by Leiden University. FT-O is supported by the German Research Foundation, grant DFG Research Unit FOR2107.

Author information

Authors and Affiliations

Authors

Contributions

Concept and design: all authors. Drafting of the manuscript: MLM. Critical revision of the manuscript for important intellectual content: all authors.

Corresponding author

Correspondence to M. L. Molendijk.

Ethics declarations

Competing interests

The authors declare no competing interests. PM reports to have received research grants from the Ministry of Education (Spain), the Government of Navarra (Spain), the Spanish Foundation of Psychiatry and Mental Health and AstraZeneca; he is a clinical consultant for MedAvanteProPhase and has received lecture honoraria from or has been a consultant for AB-Biotics, Guidepoint, Janssen, Novumed, Roland Berger and Scienta. All are unrelated to the current work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Molendijk, M.L., Molero, P., Thomas-Odenthal, F. et al. There is not much to mediate [yet] when it comes to diet and depression. Mol Psychiatry 27, 776–777 (2022). https://doi.org/10.1038/s41380-021-01382-w

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41380-021-01382-w

Search

Quick links