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Data availability
The single-cell RNA-seq data generated during the current study is available in the Gene Expression Omnibus database under accession code GSE231523. Computer code used to generate these results is available on GitHub at https://github.com/Lipinski-B/Flinovo.
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Acknowledgements
The authors thank the Institut Carnot Calym for having provoked the scientific collaboration and provided access to the CeVi_Collection. The authors also thank the Centre de Ressources Biologiques CRB-Sud from Hospices Civils de Lyon, Lyon Sud hospital pharmacy department for having provided RCHOP compounds. We thank Yann Guillermin for his help in data collection. We thank Sabrina Baaklini, Pierre Milpied, Bertrand Nadel, Jerome Tamburini, and Bruno Tesson for helpful scientific discussions. We acknowledge the contribution of SFR Biosciences (UAR3444/CNRS, US8/Inserm, ENS de Lyon, UCBL) lentivectors production facility (Gerland) and cytometry facility (Lyon Sud).
Funding
This work was supported by grants from the Agence Nationale de la Recherche (ANR-19-CE17-005-01) and financial support from the Hospices Civils de Lyon.
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MZ, LG, VC, CD-B, and PS conceptualized the study and acquired fundings; MZ, BL, CC, LJ, RT, ML, AV, and JG, performed the investigations; MZ, BL, CC, LJ, RT, EJ, ML, VC, CD-B, and PS designed the methodology; AT-G, EB, GS, SH, PS provided resources; MZ, RT, VC, CD-B, and PS supervised the study; MZ and PS wrote the original draft.
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CC, LJ, ML and RT are employed by Oncofactory, an ERBC company. VC and CDB are co-founders of Oncofactory SAS.
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Zala, M., Lipinski, B., Costechareyre, C. et al. Functional precision oncology for follicular lymphoma with patient-derived xenograft in avian embryos. Leukemia 38, 430–434 (2024). https://doi.org/10.1038/s41375-024-02150-9
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DOI: https://doi.org/10.1038/s41375-024-02150-9