Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Journal Club
  • Published:

Safety and efficacy of antenatal glucocorticoids in women at risk of preterm birth in low resource settings

Journal of Perinatology volume 42, pages 149–152 (2022)Cite this article

Subjects

Does intramuscular dexamethasone compared to placebo, given to women at risk of preterm birth from 26 weeks 0 days to 33 weeks 6 days of gestational age, decreases the incidence of neonatal death, stillbirth or neonatal death without an increase in maternal infection in the initial 28 days after delivery?

Study design: Multicenter, parallel-group, double-blinded, placebo-controlled, randomized clinical trial.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. WHO ACTION Trials Collaborators, Oladapo OT, Vogel JP, Piaggio G, Nguyen M-H, Althabe F, et al. Antenatal dexamethasone for early preterm birth in low-resource countries. N Engl J Med. 2020;383:2514–25.

    Article  Google Scholar 

  2. Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2017. https://doi.org/10.1002/14651858.CD004454.pub3.

  3. Bonanno C, Wapner RJ. Antenatal corticosteroid treatment: what’s happened since Drs Liggins and Howie? Am J Obstet Gynecol. 2009;200:448–57.

    Article  CAS  Google Scholar 

  4. Vyas J, Kotecha S. Effects of antenatal and postnatal corticosteroids on the preterm lung. Arch Dis Child Fetal Neonatal Ed. 1997;77:F147–50.

    Article  CAS  Google Scholar 

  5. Althabe F, Belizán JM, McClure EM, Hemingway-Foday J, Berrueta M, Mazzoni A, et al. A population-based, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: the ACT cluster-randomised trial. Lancet. 2015;385:629–39.

    Article  Google Scholar 

  6. Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita ATN, Reddy UM, Saade GR, et al. Antenatal betamethasone for women at risk for late preterm delivery. N Engl J Med. 2016;374:1311–20.

    Article  CAS  Google Scholar 

  7. Butt K, Lim K.Diagnostic Imaging Committee Determination of gestational age by ultrasound. J Obstet Gynaecol Can JOGC. 2014;36:171–81.

    Article  Google Scholar 

  8. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol. 1995;57:289–300.

    Google Scholar 

  9. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer. 1976;34:585–612.

    Article  CAS  Google Scholar 

  10. Haybittle JL. Repeated assessment of results in clinical trials of cancer treatment. BJR. 1971;44:7.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From Department of Neonatology, All India Institute of Medical science, Bhubaneswar, Odisha, 751019, India

    M. Zakiulla, P. Mishra & T. Sahoo

Authors
  1. M. Zakiulla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Mishra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Sahoo
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MZ: Wrote the first draft, did literature search and critical appraisal for the journal club. PM: Wrote the first draft, did the literature search pertaining to biostatistics and revised the manuscript. TS: Approved both first draft as well as revised draft. Cross checked available literature pertaining to journal club. She is the final guarantee of the paper

Corresponding author

Correspondence to T. Sahoo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Manuscript citation: WHO ACTION Trials Collaborators, Oladapo OT, Vogel JP, Piaggio G, Nguyen M-H, Althabe F, et al. Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries. N Engl J Med. 2020 Dec 24;383(26):2514–25.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zakiulla, M., Mishra, P. & Sahoo, T. Safety and efficacy of antenatal glucocorticoids in women at risk of preterm birth in low resource settings. J Perinatol 42, 149–152 (2022). https://doi.org/10.1038/s41372-021-01244-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-021-01244-x

Search

Advanced search

Quick links