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ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E

International Journal of Obesity volume 45, pages 2286–2287 (2021)Cite this article

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We would like to thank the Editor for giving us the opportunity to respond to the comments made by Dr. Poledne R. et al. regarding our recent publication, “ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E” [1]. We also thank Dr. Poledne R. et al. for reading our work and appreciate their comment.

The authors have offered an alternative explanation for our findings. They suggest for our phenotype to be the result of changes in adipose tissue macrophage polarization. Although this would seem to be a reasonable interpretation of our data, we want to caution the authors on reaching such a conclusion. Indeed, we did not determine for the observed increase in APOE levels to be the principle mechanism responsible for the anti-inflammatory effect of fish oil supplementation. We proposed for APOE to play a role in this effect and postulated for a non-adipocyte source to decrease inflammation without an apparent change in macrophage number.

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References

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Funding

EDF received support by Arizona Department of Health Services, Arizona Biomedical Research Commission (ABRC) (ADHS14-00003606), the Katryn H. and Roger Penske Career Development Award in Endocrinology in Honor of Dr Ian Hay, and Mayo Foundation, KL2 TR002379-02-01 CTSA.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic Arizona, Scottsdale, AZ, USA

    James D. Hernandez, Ting Li & Eleanna De Filippis

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  1. James D. Hernandez
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  2. Ting Li
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  3. Eleanna De Filippis
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Correspondence to Eleanna De Filippis.

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Hernandez, J.D., Li, T. & De Filippis, E. ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E. Int J Obes 45, 2286–2287 (2021). https://doi.org/10.1038/s41366-021-00882-7

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