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Mouse fertility is not dependent on the CREB coactivator Crtc1

Nature Medicine volume 15, pages 989–990 (2009)Cite this article

To the Editor:

Cyclic AMP response element–binding protein (CREB)-regulated transcription coactivators (Crtcs), also known as transducers of regulated CREB activity (TORCs), are coactivators that function as calcium- and cyclic AMP–sensitive coincidence detectors1,2. Ubiquitously expressed Crtc2 is a key regulator of energy metabolism modulating gluconeogenesis and insulin signaling3,4,5. Crtc1 is primarily expressed in the brain, where its functions still need to be determined more clearly. Our previous work showed that Crtc1 is required for the maintenance of late-phase long-term potentiation in the mammalian hippocampus, suggesting that it may be involved in learning and memory processes6.

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Figure 1: Crtc1−/− mice are obese but not infertile.

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Acknowledgements

We are grateful to E. Hummler for helpful discussions and advice. We thank A. Porret, M.-J. Voirol and M. Giacomini for excellent technical assistance and A. Caraty (University of Tours) for the kisspeptin-10 antiserum. This work was supported by grants from the Swiss National Science Foundation (3100A0-120699 and 320030-124886), the Jérôme Lejeune Foundation and the Société Académique Vaudoise.

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  1. Services of Endocrinology, Diabetology and Metabolism, University Medical Center, University of Lausanne, Lausanne, Switzerland.

Authors and Affiliations

  1. Center for Psychiatric Neuroscience, Lausanne, Switzerland

    Lionel Breuillaud, Pierre J Magistretti & Jean-René Cardinaux

  2. Department of Psychiatry, Service of Child and Adolescent Psychiatry, University Medical Center, University of Lausanne, Lausanne, Switzerland

    Lionel Breuillaud, Olivier Halfon, François P Pralong & Jean-René Cardinaux

  3. Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Pierre J Magistretti

Authors
  1. Lionel Breuillaud
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Correspondence to Jean-René Cardinaux.

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Breuillaud, L., Halfon, O., Magistretti, P. et al. Mouse fertility is not dependent on the CREB coactivator Crtc1. Nat Med 15, 989–990 (2009). https://doi.org/10.1038/nm0909-989

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