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Reply to “Heritable germline epimutation is not the same as transgenerational epigenetic inheritance”

Nature Genetics volume 39, pages 575–576 (2007)Cite this article

Suter and Martin reply:

We agree1 that the findings of Chan and co-workers2 are likely to result from a germline genetic aberration that predisposes to somatic epimutation in cis. But we disagree with the criticisms of work on the MLH1 germline epimutations3,4. Whitelaw and co-workers5 conflate a variety of different phenomena; Hortshemke6 dismisses the evidence that the MLH1 epimutation is present in germline cells.

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References

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Authors and Affiliations

  1. Victor Chang Cardiac Research Institute, Sydney, Australia

    Catherine M Suter

  2. Children's Hospital Oakland Research Institute, Oakland, California, USA

    David IK Martin

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  1. Catherine M Suter
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  2. David IK Martin
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Suter, C., Martin, D. Reply to “Heritable germline epimutation is not the same as transgenerational epigenetic inheritance”. Nat Genet 39, 575–576 (2007). https://doi.org/10.1038/ng0507-575

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