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Is combined therapy with levothyroxine and liothyronine effective in patients with primary hypothyroidism?

Nature Clinical Practice Endocrinology & Metabolism volume 1, pages 18–19 (2005)Cite this article

boxed-textAppelhof B et al. (2005) Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. J Clin Endocrinol Metab 90: 2666–2674

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References

  1. Mandel SJ et al. (1993) Levothyroxine therapy in patients with thyroid disease. Ann Intern Med 119: 492–502

    Article  CAS  Google Scholar 

  2. Bunevicius R et al. (1999) Effects of thyroxine as compared with thyroxine plus tri-iodothyronine in patients with hypothyroidism. N Engl J Med 340: 424–429

    Article  CAS  Google Scholar 

  3. Cooper DS (2003) Combined T4 and T3 therapy—back to the drawing board. JAMA 290: 3002–3004

    Article  CAS  Google Scholar 

  4. Saravanan P et al. (2005) Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial. J Clin Endocrinol Metab 90: 805–812

    Article  CAS  Google Scholar 

  5. Escobar-Morreale HF et al. (2005) Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med 142: 412–424

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Marie Lofthouse, Assistant Editor, Nature Clinical Practice.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, University Hospital of Pisa,

    Aldo Pinchera & Ferruccio Santini

  2. Postgraduate School of Endocrinology, University of Pisa, Italy

    Aldo Pinchera & Ferruccio Santini

Authors
  1. Aldo Pinchera
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  2. Ferruccio Santini
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Corresponding author

Correspondence to Aldo Pinchera.

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Competing interests

The authors received research supports in the last 5 years from the pharmaceutical companies Bracco, which produces L-thyroxine preparations (Eutirox) and AMSA S.r.l., which produces both thyroxine and combined L-T4 and L-T3 preparations (Tirosint®, Tiroide Amsa)

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Pinchera, A., Santini, F. Is combined therapy with levothyroxine and liothyronine effective in patients with primary hypothyroidism?. Nat Rev Endocrinol 1, 18–19 (2005). https://doi.org/10.1038/ncpendmet0027

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