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Sentürk et al. reply

Nature volume 539, pages E6–E7 (2016)Cite this article

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replying to T. Pohlkamp et al. Nature 539, 10.1038/nature20129 (2016).

In 2011, our laboratory reported that cortical pyramidal neurons fail to migrate properly in Efnb1;2;3−/− triple knockouts and in Efnb3−/−;Reln+/− compound mice1. We provided genetic and biochemical evidence for an interaction between ephrin B (Efnb) ligands and Reelin (Reln) signalling during the development of laminated structures in the brain, such as the cortex, hippocampus and cerebellum. In the accompanying Comment2, Pohlkamp et al. now revisit this question; however they use a different Efnb3 knockout strategy.

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References

  1. Sentürk, A., Pfennig, S., Weiss, A., Burk, K. & Acker-Palmer, A. Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature 472, 356–360 (2011)

    Article  ADS  Google Scholar 

  2. Pohlkamp, T. et al. Ephrin-Bs and canonical Reelin signalling. Nature http://dx.doi.org/10.1038/nature20129 (2016)

  3. Kullander, K. et al. Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev. 15, 877–888 (2001)

    Article  CAS  Google Scholar 

  4. Yokoyama, N. et al. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron 29, 85–97 (2001)

    Article  CAS  Google Scholar 

  5. Armstrong, J. N. et al. B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus. J. Neurosci. 26, 3474–3481 (2006)

    Article  CAS  Google Scholar 

  6. Grunwald, I. C. et al. Hippocampal plasticity requires postsynaptic ephrinBs. Nat. Neurosci. 7, 33–40 (2004)

    Article  CAS  Google Scholar 

  7. Aoto, J. et al. Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. J. Neurosci. 27, 7508–7519 (2007)

    Article  CAS  Google Scholar 

  8. Bouché, E. et al. Reelin induces EphB activation. Cell Res. 23, 473–490 (2013)

    Article  Google Scholar 

  9. Catchpole, T. & Henkemeyer, M. EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche. J. Neurosci. 31, 11472–11483 (2011)

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Buchmann Institute for Molecular Life Sciences (BMLS) and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 15, Frankfurt am Main, D-60438, Germany

    A. Sentürk, S. Pfennig, A. Weiss, K. Burk & A. Acker-Palmer

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  1. A. Sentürk
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  2. S. Pfennig
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  3. A. Weiss
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  4. K. Burk
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  5. A. Acker-Palmer
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Correspondence to A. Acker-Palmer.

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Sentürk, A., Pfennig, S., Weiss, A. et al. Sentürk et al. reply. Nature 539, E6–E7 (2016). https://doi.org/10.1038/nature20130

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