Nature 514, 367–371 (2014); doi:10.1038/nature13593

While we were working on this Letter, Hou et al.1 reported the cloning of AtCSC1, an osmosensitive calcium permeable cation channel. AtCSC1 is a close homologue of OSCA1, which we identified and characterized via forward genetic screens. Whether AtCSC1 functions as an osmosensitive channel in the plasma membrane or endomembranes in planta as well as its physiological functions remains to be determined.