Whether ovarian cancer originates in the ovary or the surrounding tissues is a focus of debate. Work in mice now shows that stem cells that replenish the ovarian surface epithelium can be the initiators of this cancer. See Letter p.241
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
*This article and the paper under discussion2 were published online on 6 March 2013.
References
Sell, S. Am. J. Pathol. 176, 2584–2494 (2010).
Flesken-Nikitin, A. et al. Nature 495, 241–245 (2013).
Leushacke, M. & Barker, N. Oncogene 31, 3009–3022 (2012).
Ma, I. & Allan, A. L. Stem Cell Rev. 7, 292–306 (2011).
Silva, I. A. et al. Cancer Res. 71, 3991–4001 (2011).
Kryczek, I. et al. Int. J. Cancer 130, 29–39 (2012).
Auersperg, N. Front. Biosci. (Schol. Edn) 5, 709–719 (2013).
Dubeau, L. Gynecol. Oncol. 72, 437–442 (1999).
Piek, J. M. et al. J. Pathol. 195, 451–456 (2001).
Lee, Y. et al. J. Pathol. 211, 26–35 (2007).
Wiegand, K. C. et al. N. Engl. J. Med. 363, 1532–1543 (2010).
Yamamoto, S. et al. J. Pathol. 225, 189–194 (2011).
Lim, E. et al. Nature Med. 15, 907–913 (2009).
Bouras, T. et al. Cell Stem Cell 3, 429–441 (2008).
Visvader, J. E. Nature 469, 314–322 (2011).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Brenton, J., Stingl, J. Anatomy of an ovarian cancer. Nature 495, 183–184 (2013). https://doi.org/10.1038/nature11962
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature11962