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Structural biology

Spliceosome's core exposed

Nature volume 493, pages 615–616 (2013)Cite this article

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The spliceosome complex removes intron sequences from RNA transcripts to form messenger RNA. The structure of a spliceosomal protein, Prp8, reveals the complex's active site and casts light on the origin of splicing. See Article p.638

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Figure 1: Model of the Prp8 structure.

Prp8 graphic courtesy of W. P. Galej, Medical Research Council, UK.

Notes

  1. *This article and the paper under discussion1 were published online on 23 January 2013.

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Author information

Authors and Affiliations

  1. Charles C. Query is in the Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461-1975, USA.,

    Charles C. Query

  2. Maria M. Konarska is at the Laboratory of Molecular Biology and Biochemistry, Rockefeller University, New York, New York 10021, USA.,

    Maria M. Konarska

Authors
  1. Charles C. Query
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  2. Maria M. Konarska
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Correspondence to Charles C. Query or Maria M. Konarska.

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Query, C., Konarska, M. Spliceosome's core exposed. Nature 493, 615–616 (2013). https://doi.org/10.1038/nature11857

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