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The influences of factors associated with decreased iron supply to the fetus during pregnancy on iron status in healthy children aged 0.5 to 3 years

Journal of Perinatology volume 34, pages 229–233 (2014)Cite this article

Subjects

Abstract

Objective:

To investigate whether maternal anemia, pregnancy-induced diabetes, hypertension and smoking contributed to the recently found high prevalence of iron deficiency in a population of otherwise healthy children.

Study design:

Iron status was assessed in 400 children aged 0.5 to 3 years. We obtained information on the mothers’ laboratory results, the presence of diabetes and hypertension, smoking habits and use of medication while pregnant.

Result:

We found no influence of maternal anemia, diabetes, hypertension or smoking during pregnancy on iron status in the children. Mean corpuscular volume (MCV) values of the children were positively correlated to maternal MCV values.

Conclusion:

In this population, iron status in children is not affected by maternal anemia or maternal factors that are associated with a decreased iron transport during pregnancy. The correlation between MCV values in mothers and their children might be explained by genetic and/or shared environmental factors.

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References

  1. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW . Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 2000; 105 (4): E51.

    Article  CAS  Google Scholar 

  2. Grantham-McGregor S, Ani C . A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 2001; 131 (2S-2): 649S–666S.

    Article  CAS  Google Scholar 

  3. Fleming RE . Cord serum ferritin levels, fetal iron status, and neurodevelopmental outcomes: correlations and confounding variables. J Pediatr 2002; 140 (2): 145–148.

    Article  CAS  Google Scholar 

  4. Berglund SK, Westrup B, Hagglof B, Hernell O, Domellof M . Effects of iron supplementation of LBW infants on cognition and behavior at 3 years. Pediatrics 2013; 131 (1): 47–55.

    Article  Google Scholar 

  5. Rao R, Georgieff MK . Perinatal aspects of iron metabolism. Acta Paediatr Suppl 2002; 91 (438): 124–129.

    CAS  Google Scholar 

  6. Chaparro CM . Setting the stage for child health and development: prevention of iron deficiency in early infancy. J Nutr 2008; 138 (12): 2529–2533.

    Article  CAS  Google Scholar 

  7. McLimore HM, Phillips AK, Blohowiak SE, Pham DQ, Coe CL, Fischer BA et al. Impact of multiple prenatal risk factors on newborn iron status at delivery. J Pediatr Hematol Oncol 2012; 35 (6): 473–477.

    Article  Google Scholar 

  8. Siddappa AM, Rao R, Long JD, Widness JA, Georgieff MK . The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations. Neonatology 2007; 92 (2): 73–82.

    Article  CAS  Google Scholar 

  9. Shao J, Lou J, Rao R, Georgieff MK, Kaciroti N, Felt BT et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012; 142 (11): 2004–2009.

    Article  CAS  Google Scholar 

  10. Geltman PL, Meyers AF, Mehta SD, Brugnara C, Villon I, Wu YA et al. Daily multivitamins with iron to prevent anemia in high-risk infants: a randomized clinical trial. Pediatrics 2004; 114 (1): 86–93.

    Article  Google Scholar 

  11. Choi JW, Kim CS, Pai SH . Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. Acta Paediatr 2000; 89 (6): 675–679.

    Article  CAS  Google Scholar 

  12. Halvorsen S . Iron balance between mother and infant during pregnancy and breastfeeding. Acta Paediatr 2000; 89 (6): 625–627.

    Article  CAS  Google Scholar 

  13. Blot I, Diallo D, Tchernia G . Iron deficiency in pregnancy: effects on the newborn. Curr Opin Hematol 1999; 6 (2): 65–70.

    Article  CAS  Google Scholar 

  14. Uijterschout L, Teunisse PP, Vloemans J, Vos R, Hudig C, Bubbers S et al. Prevalence and risk factors of iron deficiency in healthy young children in the southwestern region of the Netherlands. J Pediatr Gastroenterol Nutr 2013 (e-pub ahead of print).

  15. World Health Organization. Iron deficiency anemia. Assessment, prevention and control. 2010; 1–132.

  16. de Boer J, Zeeman K, Verhoeven C Hypertensieve aandoeningen tijdens de zwangerschap, bevalling en kraamperiode. 11. 1-11-2011. 17-7-2013.

  17. Lips JP, Visser GHA, Peeters LLH, Hajenius PJ, Pajkrt E, Evers IM Diabetes mellitus en zwangerschap. Richtlijn Nederlandse Vereniging voor Obstetrie en Gynaecologie. 4-6-2010. 17-7-2013.

  18. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia; report of a WHO/IDF consultation. 2006. 17-6-2013.

  19. Jans S, Beentjes M Anemie in de verloskundige praktijk. Aanbevelingen voor preventie, diagnostiek en behandeling. 1-74. 2010. 3-6-2013. 1–74.

  20. El-Farrash RA, Ismail EA, Nada AS . Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatr Blood Cancer 2012; 58 (2): 233–238.

    Article  Google Scholar 

  21. Kilbride J, Baker TG, Parapia LA, Khoury SA, Shuqaidef SW, Jerwood D . Anaemia during pregnancy as a risk factor for iron-deficiency anaemia in infancy: a case-control study in Jordan. Int J Epidemiol 1999; 28 (3): 461–468.

    Article  CAS  Google Scholar 

  22. De PS, Bloem MW, Sari M, Kiess L, Yip R, Kosen S . The high prevalence of low hemoglobin concentration among Indonesian infants aged 3-5 months is related to maternal anemia. J Nutr 2002; 132 (8): 2215–2221.

    Article  Google Scholar 

  23. Harthoorn-Lasthuizen EJ, Lindemans J, Langenhuijsen MM . Does iron-deficient erythropoiesis in pregnancy influence fetal iron supply? Acta Obstet Gynecol Scand 2001; 80 (5): 392–396.

    Article  CAS  Google Scholar 

  24. Ervasti M, Sankilampi U, Heinonen S, Punnonen K . Early signs of maternal iron deficiency do not influence the iron status of the newborn, but are associated with higher infant birthweight. Acta Obstet Gynecol Scand 2009; 88 (1): 83–90.

    Article  CAS  Google Scholar 

  25. Bencaiova G, Burkhardt T, Breymann C . Anemia—prevalence and risk factors in pregnancy. Eur J Intern Med 2012; 23 (6): 529–533.

    Article  Google Scholar 

  26. Milman N, Pedersen AN, Ovesen L, Schroll M . Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age? Aging Clin Exp Res 2008; 20 (1): 8–14.

    Article  CAS  Google Scholar 

  27. Ohlund I, Lind T, Hornell A, Hernell O . Predictors of iron status in well-nourished 4-y-old children. Am J Clin Nutr 2008; 87 (4): 839–845.

    Article  Google Scholar 

  28. Siimes MA, Kallio MJ, Salmenpera L, Perheentupa J . Effect of heredity on hemoglobin concentration. J Pediatr 1994; 124 (1): 100–102.

    Article  CAS  Google Scholar 

  29. Faber M, Swanevelder S, Benade AJ . Is there an association between the nutritional status of the mother and that of her 2-year-old to 5-year-old child? Int J Food Sci Nutr 2005; 56 (4): 237–244.

    Article  CAS  Google Scholar 

  30. Zimmermann MB, Harrington M, Villalpando S, Hurrell RF . Nonheme-iron absorption in first-degree relatives is highly correlated: a stable-isotope study in mother-child pairs. Am J Clin Nutr 2010; 91 (3): 802–807.

    Article  CAS  Google Scholar 

  31. Land TG, Landau AS, Manning SE, Purtill JK, Pickett K, Wakschlag L et al. Who underreports smoking on birth records: a Monte Carlo predictive model with validation. PLoS One 2012; 7 (4): e34853.

    Article  CAS  Google Scholar 

  32. Pena-Rosas JP, Viteri FE . Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev 2009; (4))CD004736.

  33. Hernandez-Martinez C, Canals J, Aranda N, Ribot B, Escribano J, Arija V . Effects of iron deficiency on neonatal behavior at different stages of pregnancy. Early Hum Dev 2011; 87 (3): 165–169.

    Article  CAS  Google Scholar 

  34. Scanlon KS, Yip R, Schieve LA, Cogswell ME . High and low hemoglobin levels during pregnancy: differential risks for preterm birth and small for gestational age. Obstet Gynecol 2000; 96 (5 Pt 1): 741–748.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Juliana Children’s Hospital – Haga Teaching Hospital, The Hague, The Netherlands

    L Uijterschout, J Vloemans, L Rövekamp-Abels & F Brus

  2. Department of Gynaecology, Haga Teaching Hospital, The Hague, The Netherlands

    H Feitsma

  3. Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands

    J B van Goudoever

  4. Department of Pediatrics, Emma Children’s Hospital – Academic Medical Center, Amsterdam, The Netherlands

    J B van Goudoever

Authors
  1. L Uijterschout
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  2. J Vloemans
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  3. L Rövekamp-Abels
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  4. H Feitsma
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  5. J B van Goudoever
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  6. F Brus
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Correspondence to L Uijterschout.

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Uijterschout, L., Vloemans, J., Rövekamp-Abels, L. et al. The influences of factors associated with decreased iron supply to the fetus during pregnancy on iron status in healthy children aged 0.5 to 3 years. J Perinatol 34, 229–233 (2014). https://doi.org/10.1038/jp.2013.163

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