Abstract
Arterial thromboembolism (TE) in the absence of current or recent history of a central catheter is a rare condition in newborn period. We report a case of severe lower extremities arterial TE of unclear etiology in a full-term neonate. By adding hyperbaric oxygenation to thrombolytic and antithrombotic therapy, we achieved improved perfusion of the upper leg tissues, preserving the knee and enabling below-the-knee amputation.
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References
Chalmers E . Neonatal thrombosis. J Clin Pathol 2000; 53(6): 419–423.
Albisetti M, Schmugge M, Haas R, Eckhardt BP, Bauersfeld U, Baenziger O et al. Arterial thromboembolic complications in critically ill children. J Crit Care 2005; 20(3): 296–300.
Gurgey A, Tekinalp G, Cinar A, Cakmak F . Symptomatic thrombosis in Turkish neonates. J Pediatr Hematol Oncol 2004; 26(7): 417–420.
Shmeleva VM, Kapustin SI, Papayan LP, Sobczynska-Malefora A, Harrington DJ, Savidge GF . Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia. Thromb Res 2003; 111(6): 351–356.
Gupta PK, Ahmed RP, Bhattacharyya M, Kannan M, Biswas A, Kalra V et al. Protein C system defects in Indian children with thrombosis. Ann Hematol 2005; 84(2): 85–88. (E-pub September 23, 2004).
Manco-Johnson MJ, Nuss R, Hays T, Krupski W, Drose J, Manco-Johnson ML . Combined thrombolytic and anticoagulant therapy for venous thrombosis in children. J Pediatr 2000; 136(4): 446–453.
Waisman D, Shupak A, Weisz G, Melamed Y . Hyperbaric oxygen therapy in the pediatric patient: the experience of the Israel Naval Medical Institute. Pediatrics 1998; 102(53): E53.
Siraneci R, Hatipoglu N, Hatipoglu H, Dundar K, Baygin L, Yildiz C et al. Acute arterial thrombotic purpura complicating varicella and the role of hyperbaric oxygen as an adjunctive therapy. Turk J Pediatr 2004; 46(3): 256–258.
Mihaljevic S, Mihaljevic L, Majeric-Kogler V, Oremus K . Hyperbaric oxygenation combined with streptokinase for treatment of arterial thromboembolism of the lower leg. Wien Klin Wochenschr. 2004; 116(4): 140–142.
Acknowledgements
We would like to thank the Division of Pediatric Hematology-Oncology and Department of Orthopedic Surgery, Mattel Children's Hospital at UCLA for their expertise and help in management of the patient. Parents approved patient's therapy and the report.
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Wiebers, J., Purdy, I., Lieber, M. et al. Hyperbaric oxygen in treatment of neonatal arterial thromboembolism of lower extremities. J Perinatol 26, 777–779 (2006). https://doi.org/10.1038/sj.jp.7211606
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DOI: https://doi.org/10.1038/sj.jp.7211606