Sir,
We are encouraged by the clinico-pathological evidence provided by Vermeulen et al (2009) in support of the self-metastasis concept, and in particular, that the self-metastatic dynamic is a logical mechanism for understanding a characteristic invasive fingering morphology driven by migratory cell types in inflammatory breast carcinoma (IBC). In their argument, Vermeulen et al re-emphasise the importance of cancer stem cells in the in silico model to seed new separate clusters (Enderling et al, 2009), and that a stem-cell-like phenotype is expressed in lymphovascular emboli in vivo as well as in IBC patients. The clinical features of IBC – fast local growth and efficient metastasis (with almost all patients having lymph node metastases and about one-third having distant metastases) – motivate a straightforward extension of the self-metastasis model to also explain the formation of distant metastases. Tumours that grow in a self-metastatic manner have a large distribution of stem cells in self-seeded clusters at the tumour periphery, and it is these cancer stem cells that would potentially intravasate into nearby vessels to drive intra-vascular growth and seed distant metastases. In a preliminary test of this idea, we found that self-metastatic tumours have a preferred tendency to shed cancer stem cells well into extra-tumoral tissue, where they can either form local self-metastases or enter the blood stream to potentially form distant metastases. Tumours that do not exhibit the self-metastatic phenotype, by contrast, prove to be slow growing and unable to seed stem cells either to areas adjacent to the primary site or to distant sites. In closing, we appreciate the contribution of Vermeulen et al in providing very important clinical and pathological correlations that further support the self-metastasis concept, and by extension, a more unified basis for understanding local and distant tumour dissemination.
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16 November 2011
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References
Enderling H, Hlatky L, Hahnfeldt P (2009) Migration rules: tumours are conglomerates of self-metastases. Br J Cancer 100 (12): 1917–1925
Vermeulen PB, Van Laere SJ, Dirix LY (2009) Inflammatory breast carcinoma as a model of accelerated self-metastasic expansion by intra-vascular growth. Br J Cancer (e-pub ahead of print 25 August 2009)
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Enderling, H., Hlatky, L. & Hahnfeldt, P. Reply: Inflammatory breast carcinoma as a model of accelerated self-metastatic expansion by intra-vascular growth. Br J Cancer 101, 1030 (2009). https://doi.org/10.1038/sj.bjc.6605252
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DOI: https://doi.org/10.1038/sj.bjc.6605252