Modifications of DNA-associated histone proteins maintain genome integrity. On damage to DNA, phosphorylation of histone H2A.X determines whether repair is justified or if the damaged cell must die.
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References
Groth, A., Rocha, W., Verreault, A. & Almouzni, G. Cell 128, 721–733 (2007).
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. J. Biol. Chem. 273, 5858–5868 (1998).
Fernandez-Capetillo, O., Lee, A., Nussenzweig, M. & Nussenzweig, A. DNA Repair 3, 959–967 (2004).
Bartek, J. & Lukas, J. Curr. Opin. Cell Biol. 19, 238–245 (2007).
Xiao, A. et al. Nature 457, 57–62 (2009).
Cook, P. J. et al. Nature 458, 591–596 (2009).
Poot, R. A. et al. Nature Cell Biol. 6, 1236–1244 (2004).
Bozhenok, L., Wade, P. A. & Varga-Weisz, P. EMBO J. 21, 2231–2241 (2002).
Stucki, M. et al. Cell 123, 1213–1226 (2005).
Lukas, C. et al. EMBO J. 23, 2674–2683 (2004).
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Lukas, J., Bartek, J. New tales of an old tail. Nature 458, 581–583 (2009). https://doi.org/10.1038/458581a
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DOI: https://doi.org/10.1038/458581a