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  • Vaccines and Autism
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Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder

Molecular Psychiatry volume 7, pages S47–S48 (2002)Cite this article

A novel form of inflammatory bowel disease has been reported in a cohort of children with developmental disorder, manifesting predominantly as regressive autism (affected children). The intestinal pathology includes ileo-colonic lymphoid nodular hyperplasia (LNH) and a subtle enterocolitis. Clinical and pathological aspects of this disorder have previously been reported.1,2,3

In ileal lymphoid tissues of affected children, the presence of reactive follicular hyperplasia may reflect antigenic presence at this site. We have examined a possible association between measles virus (MV) and a chronic enterocolitis in these children. We sought to detect and localise MV in intestinal tissues from affected children.

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Authors and Affiliations

  1. Department of Pathology, Coombe Women's Hospital, Dublin, Ireland

    C M Martin, V Uhlmann, A Killalea & J J O'Leary

  2. Trinity College, Dublin, Ireland

    C M Martin, O Sheils & J J O'Leary

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  1. C M Martin
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  2. V Uhlmann
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  3. A Killalea
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  4. O Sheils
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  5. J J O'Leary
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Correspondence to C M Martin.

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Martin, C., Uhlmann, V., Killalea, A. et al. Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder. Mol Psychiatry 7 (Suppl 2), S47–S48 (2002). https://doi.org/10.1038/sj.mp.4001179

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