Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

Glowing switches

An approach involving changes in the emission of fluorescence reveals new information about the activation of two important molecular switches in real time and space.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The technique used by Mochizuki et al.1 to analyse the activation of Ras, a small GTPase enzyme, in real time and space.
Figure 2: Ras and Rap1 are active in different parts of the cell.

References

  1. Mochizuki, N. et al. Nature 411, 1065–1068 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Kraynov, V. S. et al. Science 290, 333–337 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Bos, J. L. EMBO J. 17, 6776–6782 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. York, R. D. et al. Mol. Cell. Biol. 20, 8069–8083 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bos, J. L., De Rooij, J. & Reedquist, K. A. Nature Rev. Mol. Cell Biol. 2, 369–377 (2001).

    Article  CAS  Google Scholar 

  6. Pizon, V., Desjardins, M., Bucci, C., Parton, R. G. & Zerial, M. J. Cell Sci. 107, 1661–1670 (1994).

    CAS  PubMed  Google Scholar 

  7. Lemmon, S. K. & Traub, L. M. Curr. Opin. Cell Biol. 12, 457–466 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Quinn, M. T. et al. Blood 79, 1563–1573 (1992).

    CAS  PubMed  Google Scholar 

  9. Ozaki, N. et al. Nature Cell Biol. 2, 805–811 (2000).

    Article  CAS  PubMed  Google Scholar 

  10. Gulli, M.-P & Peter, M. Genes Dev. 15, 365–377 (2001).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Johannes L. Bos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bos, J. Glowing switches. Nature 411, 1006–1007 (2001). https://doi.org/10.1038/35082667

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35082667

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing