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Developmental biology

Making head or tail of Dickkopf

Signals that guide embryonic cells through development are often under the control of inhibitors. It now seems that one such inhibitor does not bind to the signal itself, but rather to the receptor that detects the signal.

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Figure 1: Events inside and outside the cell during Wnt signalling in development, based on recent results2,14,15.

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Correspondence to Roel Nusse.

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Nusse, R. Making head or tail of Dickkopf. Nature 411, 255–256 (2001). https://doi.org/10.1038/35077199

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