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Developmental model for thalidomide action

Nature volume 400, pages 419–420 (1999)Cite this article

Abstract

Tabin has proposed a progress-zone model1, based on published data, to explain the inhibition of limb morphogenesis by thalidomide. We do not think that his model convincingly explains the main features of thalidomide action.

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References

  1. Tabin, C. J. Nature 396, 322–323 (1998).

    Google Scholar 

  2. Neubert, R. & Neubert, D. in Drug Toxicity in Embryonic Development (eds Kavlock, R. J. & Daston, G. P.) 44–119 (Springer, Berlin, 1997).

  3. Streeter, G. L. Contrib. Embryol. Carneg. Inst. 31, 27–63 (1945).

    Google Scholar 

  4. Streeter, G. L. Contrib. Embryol. Carneg. Inst. 32, 133–203 (1948).

    Google Scholar 

  5. Merker, H.-J., Heger, W., Sames, K., Stürje, H. & Neubert, D. Arch. Toxicol. 61, 165–179 (1988).

    Google Scholar 

  6. Neubert, D., Heger, W., Merker, H.-J., Sames, K. & Meister, R. Arch. Toxicol. 61, 180–191 (1988).

    Google Scholar 

  7. Christ, B. et al. Anat. Embryol. 150, 171–186 (1977).

    Google Scholar 

  8. Theisen, C. T. & McGregor, E. E. Teratology 23, 65A (1981).

  9. Neubert, R., Hinz, N., Thiel, R. & Neubert, D. Life Sci. 58, 295–316 (1996).

    Google Scholar 

  10. Neubert, R., Hinz, N. & Thiel, R. in Methods in Developmental Toxicology/Biology (eds Klug, S. & Thiel, R.) 209–226 (Blackwell, Berlin, 1997).

  11. Springer, T. A. Nature 346, 425–434 (1990).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Clinical Pharmacology,

    Reinhard Neubert & Diether Neubert

  2. Toxicology, and Institute of Anatomy, Benjamin Franklin Medical Centre, Freie Universität, Berlin, 14195, Germany

    Hans-Joachim Merker

Authors
  1. Reinhard Neubert
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  2. Hans-Joachim Merker
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  3. Diether Neubert
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Neubert, R., Merker, HJ. & Neubert, D. Developmental model for thalidomide action. Nature 400, 419–420 (1999). https://doi.org/10.1038/22685

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