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The link between obesity and allergy: a role of ACP1 genetic polymorphism?

International Journal of Obesity volume 31, pages 392–393 (2007)Cite this article

In a recent commentary1 on the relationship between asthma and obesity, Weiss has stressed that ‘among the most interesting area of research in this field, is the possible inter-relationship between genes known to be important in asthma that may also be important in obesity’. Pleiotropic genes could have an important role in both complex traits. This interesting concept prompted us to compare the association between ACP1 genetic polymorphism and obesity previously described by us2 with more recent data showing a relationship between ACP1 and allergy.

ACP1 is a polymorphic gene located on chromosome 2 showing three common codominant alleles: ACP1*A, ACP1*B and ACP1*C. These three alleles are associated with different enzymatic activity. At present, the term ACP1 is used to indicate the gene, whereas the protein product is called LMPTP (Low Molecular Weight Protein Tyrosine Phosphatase). Two functions have been suggested for LMPTP: flavin mononucleotide phosphatase and protein tyrosine phosphatase. By catalyzing the conversion of flavin mononucleotide to riboflavin, LMPTP may have a role in regulating the cellular concentration of flavin adenine dinucleotide, flavo enzyme activity and energy metabolism. As protein tyrosine phosphatase, the enzyme may have an important role in modulation of glycolytic rate through the control of insulin receptor activities and of band 3 protein phosphorylation (see Bottini et al.3 for review).

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References

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Authors and Affiliations

  1. Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy

    F Gloria-Bottini

  2. Department of Internal Medicine, School of Medicine, University of Rome Tor Vergata, Rome, Italy

    N Bottini

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  1. F Gloria-Bottini
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  2. N Bottini
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Correspondence to F Gloria-Bottini.

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Gloria-Bottini, F., Bottini, N. The link between obesity and allergy: a role of ACP1 genetic polymorphism?. Int J Obes 31, 392–393 (2007). https://doi.org/10.1038/sj.ijo.0803396

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