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| Open AccessExpanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation
- Changsheng Wu
- , Boris Zacchetti
- & Young Hae Choi
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| Open AccessDiscovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase
- Tian-Ying Xu
- , Sai-Long Zhang
- & Chao-Yu Miao
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| Open AccessA new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity
- Hongbo Chen
- , Xiaobin Zeng
- & Lin Mei
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| Open AccessEfficacy comparison between cryoablation and radiofrequency ablation for patients with cavotricuspid valve isthmus dependent atrial flutter: a meta-analysis
- Yi-He Chen
- , Hui Lin
- & Yi-Gang Li
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| Open AccessA Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates
- Meimei Chen
- , Xiaohui Ye
- & Yi Kong
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| Open AccessNontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies
- Sahabudeen Sheik Mohideen
- , Yasutoyo Yamasaki
- & Yuji Yoshiike
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| Open AccessDirect Identification of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System for High-Throughput Bioanalysis
- Homan Kang
- , Sinyoung Jeong
- & Yoon-Sik Lee
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| Open AccessThe cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress
- Ping Lu
- , Marieke H. Heineke
- & Dirk Bald
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| Open AccessShear induced carboplatin binding within the cavity of a phospholipid mimic for increased anticancer efficacy
- Jingxin Mo
- , Paul K. Eggers
- & Colin L. Raston
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| Open AccessJBP485 promotes tear and mucin secretion in ocular surface epithelia
- Takahiro Nakamura
- , Yuiko Hata
- & Shigeru Kinoshita
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| Open AccessQuantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor
- Caitlin Lynch
- , Jinghua Zhao
- & Hongbing Wang
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| Open AccessCurcumin-Encapsulated Polymeric Micelles Suppress the Development of Colon Cancer In Vitro and In Vivo
- Xi Yang
- , Zhaojun Li
- & Changyang Gong
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Article
| Open AccessHippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model
- Jin-Seok Lee
- , Hyeong-Geug Kim
- & Chang-Gue Son
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| Open AccessMarine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer
- Goutam Dey
- , Rashmi Bharti
- & Mahitosh Mandal
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| Open AccessEffect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis
- Joseph P. Tiano
- , Chandra R. Tate
- & Franck Mauvais-Jarvis
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| Open AccessA method for human teratogen detection by geometrically confined cell differentiation and migration
- Jiangwa Xing
- , Yi-Chin Toh
- & Hanry Yu
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| Open AccessA novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
- Octavian Bucur
- , Gabriel Gaidos
- & Roya Khosravi-Far
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| Open AccessTubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity
- Wei Zhao
- , Jia-Ke Bai
- & Ya-Jie Tang
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| Open AccessToxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel
- Zongyun Chen
- , Youtian Hu
- & Yingliang Wu
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| Open AccessStructure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking
- Margherita Brindisi
- , Simone Brogi
- & Giuseppe Campiani
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| Open AccessDesign, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
- Rubén Ferreira
- , Jesper R. Nilsson
- & Morten Grøtli
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| Open AccessA metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice
- Wei Chen
- , Rong Gao
- & Lili Wang
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| Open AccessRecombinant Mutated Human TNF in Combination with Chemotherapy for Stage IIIB/IV Non-Small Cell Lung Cancer: A Randomized, Phase III Study
- Xiaowen Ma
- , Yang Song
- & Meng Li
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| Open AccessPredicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial
- Miao Jiang
- , Qinglin Zha
- & Aiping Lu
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| Open AccessPotent effects of dioscin against liver fibrosis
- Xiaoling Zhang
- , Xu Han
- & Jinyong Peng
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| Open AccessA decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis
- Lu Wang
- , Guan-ya Guo
- & Dai-ming Fan
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| Open AccessSmall Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations
- Chantelle J. Capicciotti
- , Jayme D. R. Kurach
- & Robert N. Ben
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| Open AccessKRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines
- João Lavrado
- , Hugo Brito
- & Alexandra Paulo
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| Open AccessIdentification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis
- Chang Liu
- , Tingting Feng
- & Shuyi Si
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| Open AccessPHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment
- Wing Lam
- , Zaoli Jiang
- & Yung-Chi Cheng
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| Open AccessToll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo
- Aitak Farzi
- , Juraj Halicka
- & Peter Holzer
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| Open AccessGLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1
- Krishan Kumar
- , Sania S. Raza
- & Hidayatullah G. Munshi
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| Open AccessClustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites
- Lin Tao
- , Feng Zhu
- & Yu Zong Chen
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| Open AccessBiochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”
- Yingmin Zhu
- , Haijun Chen
- & Xiaodong Cheng
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| Open AccessRole of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector
- Mustafa M. Munye
- , Jascindra Ravi
- & Stephen L. Hart
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| Open AccessIndole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death
- Fu-qian Wang
- , Qing-yi Tong
- & Yong-hui Zhang
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| Open AccessbFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway
- Zhou-Guang Wang
- , Yue Wang
- & Jian Xiao
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| Open AccessA magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging
- Haruki Eguchi
- , Masanari Umemura
- & Yoshihiro Ishikawa
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| Open AccessProgranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice
- Yun-peng Zhao
- , Qing-yun Tian
- & Chuan-ju Liu
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| Open AccessApoptotic effect of novel Schiff Based CdCl2(C14H21N3O2) complex is mediated via activation of the mitochondrial pathway in colon cancer cells
- Maryam Hajrezaie
- , Mohammadjavad Paydar
- & Mahmood Ameen Abdulla
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| Open AccessNew Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis
- Yin Nian
- , Jing Yang
- & Ming-Hua Qiu
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| Open AccessProtein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery
- Hugo M. Botelho
- , Inna Uliyakina
- & Margarida D. Amaral
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| Open AccessProlonged-acting, Multi-targeting Gallium Nanoparticles Potently Inhibit Growth of Both HIV and Mycobacteria in Co-Infected Human Macrophages
- Prabagaran Narayanasamy
- , Barbara L. Switzer
- & Bradley E. Britigan
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| Open AccessCombination of angiotensin-(1–7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy
- Panpan Hao
- , Jianmin Yang
- & Yun Zhang
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| Open AccessNew Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource
- Imanol Peña
- , M. Pilar Manzano
- & J. Julio Martin
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| Open AccessHDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation
- Meng Zhang
- , River Charles
- & Gang Ren
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| Open AccessProtein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors
- Nikhil Bhalla
- , Mirella Di Lorenzo
- & Pedro Estrela
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| Open AccessA cell-based screening system for anti-influenza A virus agents
- Wan Ying Wong
- , Sheng Wei Loh
- & Chee-Kwee Ea
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| Open AccessUsing visual lateralization to model learning and memory in zebrafish larvae
- Madelene Åberg Andersson
- , Fredrik Ek
- & Roger Olsson