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Optical coherence tomography biomarkers in preterm infants with and without retinopathy of prematurity: fallacies and facts

Eye (2024)Cite this article

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Dear Editor,

The recent publication from Belenje et al. [1] evaluating the optical coherence tomography (OCT) biomarkers to differentiate favourable and unfavourable responders to anti-vascular endothelial growth factor (VEGF) in retinopathy of prematurity (ROP) presented the following findings: hyperreflectivity of the inner retinal layers and choroidal thinning as indicators of unfavourable outcomes and cystic changes at the fovea as a favourable marker to anti-VEGF.

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Fig. 1: Pseudo-hyperreflectivity in an infant without ROP.
Fig. 2: Fallacies of imaging hyperreflectivity in the inner retina layers.

References

  1. Belenje A, Reddy RU, Parmeswarappa DC, Padhi TR, Subbarao B, Jalali S. Evaluation of optical coherence tomography biomarkers to differentiate favourable and unfavourable responders to intravitreal anti-vascular endothelial growth factor treatment in retinopathy of prematurity. Eye (London) 2023. https://doi.org/10.1038/s41433-023-02824-1

  2. Mangalesh S, McGeehan B, Tai V, Chen X, Tran-Viet D, Vajzovic L. Study of Eye Imaging in Preterm Infants Group et al. Macular OCT characteristics at 36 weeks’ postmenstrual age in infants examined for retinopathy of prematurity. Ophthalmol Retin. 2021;5:580–92.

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Authors and Affiliations

  1. Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India

    Anand Vinekar

  2. Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA

    Shwetha Mangalesh

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  1. Anand Vinekar
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  2. Shwetha Mangalesh
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Correspondence to Anand Vinekar.

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Vinekar, A., Mangalesh, S. Optical coherence tomography biomarkers in preterm infants with and without retinopathy of prematurity: fallacies and facts. Eye (2024). https://doi.org/10.1038/s41433-024-03061-w

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